Expression of SCG3 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SCG3
Gene description	Secretogranin III
Protein class	Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (glioma, pancreatic cancer)
HPA (cell line):	Group enriched (NTERA-2, SCLC-21H, SH-SY5Y)
HPA (normal tissue):	Tissue enriched (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in CNS, islets of Langerhans, adrenal medulla and a subset of cells in the gastrointestinal tract.

ANTIBODY IHC RELIABILITY
Data reliability description	External characterization data supports antibody staining. Pending external verification. Paired antibodies with high similarity supports the protein profile.
Reliability score	Supported based on 3 antibodies. HPA006880 , HPA053715 , CAB033274
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (glioma, pancreatic cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA006880	HPA053715	CAB033274

GENE INFORMATION
Gene name	SCG3 (HGNC Symbol)
Synonyms	FLJ90833, SgIII
Description	Secretogranin III (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Granins may serve as precursors for biologically active peptides. Some granins have been shown to function as helper proteins in sorting and proteolytic processing of prohormones; however, the function of this protein is unknown. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Chromosome	15
Cytoband	q21.2
Chromosome location (bp)	51681353 - 51721031
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104112 (version 83.38)
Entrez gene	29106
UniProt	Q8WXD2 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WXD2
Antibodypedia	SCG3 antibodies

PROTEIN BROWSER

SCG3-001	SCG3-002	SCG3-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SCG3-001 ENSP00000220478 ENST00000220478	Q8WXD2 [Direct mapping] Secretogranin-3 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002576 [platelet degranulation] GO:0005576 [extracellular region] GO:0007596 [blood coagulation] GO:0030168 [platelet activation] GO:0030658 [transport vesicle membrane] GO:0031410 [cytoplasmic vesicle] GO:0034774 [secretory granule lumen] GO:0044822 [poly(A) RNA binding] Show all	468 aa 53 kDa	Yes	0
SCG3-002 ENSP00000445205 ENST00000542355	Q8WXD2 [Direct mapping] Secretogranin-3 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002576 [platelet degranulation] GO:0005576 [extracellular region] GO:0007596 [blood coagulation] GO:0030168 [platelet activation] GO:0030658 [transport vesicle membrane] GO:0031410 [cytoplasmic vesicle] GO:0034774 [secretory granule lumen] GO:0044822 [poly(A) RNA binding] Show all	236 aa 26.9 kDa	No	0
SCG3-003 ENSP00000452745 ENST00000558709	H0YKC2 [Direct mapping] Secretogranin-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		57 aa 6.5 kDa	No	0