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Group enriched (caudate, cerebellum, cerebral cortex, hippocampus, hypothalamus, pituitary gland)
FANTOM5:
Group enriched (brain, caudate, cerebellum, hippocampus, pituitary gland)
Protein evidence
Evidence at protein level
Protein expression
Selective cytoplasmic expression in CNS, islets of Langerhans, adrenal medulla and a subset of cells in the gastrointestinal tract.
DATA RELIABILITY
Data reliability description
External characterization data supports antibody staining. Pending external verification. Paired antibodies with high similarity supports the protein profile.
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Granins may serve as precursors for biologically active peptides. Some granins have been shown to function as helper proteins in sorting and proteolytic processing of prohormones; however, the function of this protein is unknown. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
