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This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Transferases Kinases TKL Ser/Thr protein kinases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000187 [activation of MAPK activity] GO:0001961 [positive regulation of cytokine-mediated signaling pathway] GO:0002224 [toll-like receptor signaling pathway] GO:0002250 [adaptive immune response] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0002827 [positive regulation of T-helper 1 type immune response] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0004871 [signal transducer activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0006954 [inflammatory response] GO:0007165 [signal transduction] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0007254 [JNK cascade] GO:0010800 [positive regulation of peptidyl-threonine phosphorylation] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030274 [LIM domain binding] GO:0031398 [positive regulation of protein ubiquitination] GO:0031663 [lipopolysaccharide-mediated signaling pathway] GO:0031982 [vesicle] GO:0032722 [positive regulation of chemokine production] GO:0032727 [positive regulation of interferon-alpha production] GO:0032728 [positive regulation of interferon-beta production] GO:0032729 [positive regulation of interferon-gamma production] GO:0032735 [positive regulation of interleukin-12 production] GO:0032743 [positive regulation of interleukin-2 production] GO:0032755 [positive regulation of interleukin-6 production] GO:0032760 [positive regulation of tumor necrosis factor production] GO:0032874 [positive regulation of stress-activated MAPK cascade] GO:0033091 [positive regulation of immature T cell proliferation] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034134 [toll-like receptor 2 signaling pathway] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034146 [toll-like receptor 5 signaling pathway] GO:0034162 [toll-like receptor 9 signaling pathway] GO:0034166 [toll-like receptor 10 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway] GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] GO:0042098 [T cell proliferation] GO:0042803 [protein homodimerization activity] GO:0042981 [regulation of apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043234 [protein complex] GO:0043330 [response to exogenous dsRNA] GO:0045087 [innate immune response] GO:0045627 [positive regulation of T-helper 1 cell differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046330 [positive regulation of JNK cascade] GO:0046641 [positive regulation of alpha-beta T cell proliferation] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050700 [CARD domain binding] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050830 [defense response to Gram-positive bacterium] GO:0050852 [T cell receptor signaling pathway] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051403 [stress-activated MAPK cascade] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway] GO:0070427 [nucleotide-binding oligomerization domain containing 1 signaling pathway] GO:0070431 [nucleotide-binding oligomerization domain containing 2 signaling pathway] GO:0070555 [response to interleukin-1] GO:0070671 [response to interleukin-12] GO:0070673 [response to interleukin-18] GO:0071222 [cellular response to lipopolysaccharide] GO:0071223 [cellular response to lipoteichoic acid] GO:0071224 [cellular response to peptidoglycan] GO:0071225 [cellular response to muramyl dipeptide]