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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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RIPK2
  • TISSUE

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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

RIPK2

Gene description

Receptor-interacting serine-threonine kinase 2

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Approved based on 2 antibodies.
HPA015273 , HPA016499
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable), pancreatic cancer (unfavourable), lung cancer (unfavourable) and urothelial cancer (favourable).
Renal cancer p<0.001
Pancreatic cancer p<0.001
Lung cancer p<0.001
Urothelial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA015273
HPA016499

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A large subset of cancer tissues showed moderate cytoplasmic positivity. Several cases of endometrial cancers showed strong cytoplasmic immunoreactivity. Most remaining cancer tissues were weakly stained or negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Adenocarcinomas of pancreas, stomach, endometrium and ovary as well as liver, cervix and breast cancers displayed weak to moderate cytoplasmic staining. Most remaining cancer tissues were weakly stained or negative.

GENE INFORMATION

Gene name

RIPK2 (HGNC Symbol)

Synonyms

CARD3, CARDIAK, RICK, RIP2

Description

Receptor-interacting serine-threonine kinase 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008]

Chromosome

8

Cytoband

q21.3

Chromosome location (bp)

89757747 - 89791063

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000104312 (version 83.38)

Entrez gene

8767

UniProt

O43353 (UniProt - Evidence at protein level)

neXtProt

NX_O43353

Antibodypedia

RIPK2 antibodies

PROTEIN BROWSER

RIPK2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RIPK2-001
ENSP00000220751
ENST00000220751
O43353 [Direct mapping]
Receptor-interacting serine/threonine-protein kinase 2
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0001961 [positive regulation of cytokine-mediated signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0002827 [positive regulation of T-helper 1 type immune response]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007254 [JNK cascade]
GO:0010800 [positive regulation of peptidyl-threonine phosphorylation]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030274 [LIM domain binding]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0031982 [vesicle]
GO:0032722 [positive regulation of chemokine production]
GO:0032727 [positive regulation of interferon-alpha production]
GO:0032728 [positive regulation of interferon-beta production]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0032743 [positive regulation of interleukin-2 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0032874 [positive regulation of stress-activated MAPK cascade]
GO:0033091 [positive regulation of immature T cell proliferation]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042098 [T cell proliferation]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043234 [protein complex]
GO:0043330 [response to exogenous dsRNA]
GO:0045087 [innate immune response]
GO:0045627 [positive regulation of T-helper 1 cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046330 [positive regulation of JNK cascade]
GO:0046641 [positive regulation of alpha-beta T cell proliferation]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050700 [CARD domain binding]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0050852 [T cell receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0070427 [nucleotide-binding oligomerization domain containing 1 signaling pathway]
GO:0070431 [nucleotide-binding oligomerization domain containing 2 signaling pathway]
GO:0070555 [response to interleukin-1]
GO:0070671 [response to interleukin-12]
GO:0070673 [response to interleukin-18]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071223 [cellular response to lipoteichoic acid]
GO:0071224 [cellular response to peptidoglycan]
GO:0071225 [cellular response to muramyl dipeptide]
Show all
540 aa
61.2 kDa
No 0

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