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Gene name

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Chromosome

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In atlas

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Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

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Searches

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Specificity

Cell line

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Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

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Antibodies

Column

 
 
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RIPK2
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

RIPK2

Gene description

Receptor-interacting serine-threonine kinase 2

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Approved based on 2 antibodies.
HPA015273 , HPA016499
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

RIPK2 (HGNC Symbol)

Synonyms

CARD3, CARDIAK, RICK, RIP2

Description

Receptor-interacting serine-threonine kinase 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008]

Chromosome

8

Cytoband

q21.3

Chromosome location (bp)

89757747 - 89791063

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000104312 (version 83.38)

Entrez gene

8767

UniProt

O43353 (UniProt - Evidence at protein level)

neXtProt

NX_O43353

Antibodypedia

RIPK2 antibodies

PROTEIN BROWSER

RIPK2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RIPK2-001
ENSP00000220751
ENST00000220751
O43353 [Direct mapping]
Receptor-interacting serine/threonine-protein kinase 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0001961 [positive regulation of cytokine-mediated signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0002827 [positive regulation of T-helper 1 type immune response]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007254 [JNK cascade]
GO:0010800 [positive regulation of peptidyl-threonine phosphorylation]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030274 [LIM domain binding]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0031982 [vesicle]
GO:0032722 [positive regulation of chemokine production]
GO:0032727 [positive regulation of interferon-alpha production]
GO:0032728 [positive regulation of interferon-beta production]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0032743 [positive regulation of interleukin-2 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0032874 [positive regulation of stress-activated MAPK cascade]
GO:0033091 [positive regulation of immature T cell proliferation]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042098 [T cell proliferation]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043234 [protein complex]
GO:0043330 [response to exogenous dsRNA]
GO:0045087 [innate immune response]
GO:0045627 [positive regulation of T-helper 1 cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046330 [positive regulation of JNK cascade]
GO:0046641 [positive regulation of alpha-beta T cell proliferation]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050700 [CARD domain binding]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0050852 [T cell receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0070427 [nucleotide-binding oligomerization domain containing 1 signaling pathway]
GO:0070431 [nucleotide-binding oligomerization domain containing 2 signaling pathway]
GO:0070555 [response to interleukin-1]
GO:0070671 [response to interleukin-12]
GO:0070673 [response to interleukin-18]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071223 [cellular response to lipoteichoic acid]
GO:0071224 [cellular response to peptidoglycan]
GO:0071225 [cellular response to muramyl dipeptide]
Show all
540 aa
61.2 kDa
No 0

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