Tissue expression of ECH1 - Summary - The Human Protein Atlas

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ECH1

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TISSUE

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CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA
MOUSE BRAIN

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	ECH1
Gene description	Enoyl CoA hydratase 1, peroxisomal
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Granular cytoplasmic expression in all tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Supported based on 2 antibodies. HPA002907 , HPA005835
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	ECH1 (HGNC Symbol)
Synonyms	HPXEL
Description	Enoyl CoA hydratase 1, peroxisomal (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-coenzyme A (CoA) hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, which contains a C-terminal peroxisomal targeting sequence, localizes to the peroxisome. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.2
Chromosome location (bp)	38815422 - 38832005
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104823 (version 83.38)
Entrez gene	1891
UniProt	Q13011 (UniProt - Evidence at protein level)
neXtProt	NX_Q13011
Antibodypedia	ECH1 antibodies

PROTEIN BROWSER

ECH1-001	ECH1-005	ECH1-007	ECH1-008	ECH1-009	ECH1-013	ECH1-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ECH1-001 ENSP00000221418 ENST00000221418	Q13011 [Direct mapping] Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005777 [peroxisome] GO:0006635 [fatty acid beta-oxidation] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016853 [isomerase activity] GO:0070062 [extracellular exosome] Show all	328 aa 35.8 kDa	No	0
ECH1-005 ENSP00000471738 ENST00000597205	M0R1A2 [Direct mapping] Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		55 aa 6 kDa	No	0
ECH1-007 ENSP00000470519 ENST00000602115	M0QZF6 [Direct mapping] Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		69 aa 7.6 kDa	No	0
ECH1-008 ENSP00000472378 ENST00000595567	M0R280 [Direct mapping] Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		17 aa 2.2 kDa	No	0
ECH1-009 ENSP00000469354 ENST00000601094	M0QXS7 [Direct mapping] Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	36 aa 4.1 kDa	No	0
ECH1-013 ENSP00000470809 ENST00000595470	M0QZW4 [Direct mapping] Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	181 aa 19.8 kDa	No	0
ECH1-015 ENSP00000472322 ENST00000601778	M0R248 [Direct mapping] Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	267 aa 29.1 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.