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CCNE1

GENERAL INFORMATION

Gene name

 CCNE1

Gene description

 Cyclin E1

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enhanced (placenta)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear and cytoplasmic expression of varying intensity in most tissues. Highest expression in testis and placenta.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 3 antibodies.
HPA018169 , CAB000308 , CAB016682
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable), liver cancer (unfavourable) and ovarian cancer (unfavourable).
Endometrial cancer p<0.001
Liver cancer p<0.001
Ovarian cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA018169
CAB000308
CAB016682

GENE INFORMATION

Gene name

 CCNE1 (HGNC Symbol)

Synonyms

 CCNE

Description

 Cyclin E1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q12

Chromosome location (bp)

 29811898 - 29824308

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105173 (version 83.38)

Entrez gene

 898

UniProt

 P24864 (UniProt - Evidence at protein level)

neXtProt

 NX_P24864

Antibodypedia

 CCNE1 antibodies

PROTEIN BROWSER
CCNE1-001
CCNE1-002
CCNE1-004
CCNE1-005
CCNE1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCNE1-001
ENSP00000262643
ENST00000262643
P24864 [Direct mapping]
G1/S-specific cyclin-E1
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000307 [cyclin-dependent protein kinase holoenzyme complex]
GO:0001547 [antral ovarian follicle growth]
GO:0001889 [liver development]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006270 [DNA replication initiation]
GO:0006468 [protein phosphorylation]
GO:0010243 [response to organonitrogen compound]
GO:0014070 [response to organic cyclic compound]
GO:0014074 [response to purine-containing compound]
GO:0016055 [Wnt signaling pathway]
GO:0016301 [kinase activity]
GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity]
GO:0019901 [protein kinase binding]
GO:0030521 [androgen receptor signaling pathway]
GO:0031100 [organ regeneration]
GO:0031670 [cellular response to nutrient]
GO:0032355 [response to estradiol]
GO:0032403 [protein complex binding]
GO:0032570 [response to progesterone]
GO:0033197 [response to vitamin E]
GO:0034097 [response to cytokine]
GO:0042493 [response to drug]
GO:0045471 [response to ethanol]
GO:0045597 [positive regulation of cell differentiation]
GO:0045859 [regulation of protein kinase activity]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048545 [response to steroid hormone]
GO:0050681 [androgen receptor binding]
GO:0051301 [cell division]
GO:0051412 [response to corticosterone]
GO:0051597 [response to methylmercury]
GO:0051726 [regulation of cell cycle]
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 410 aa
47.1 kDa 		No 0
CCNE1-002
ENSP00000410179
ENST00000444983
P24864 [Direct mapping]
G1/S-specific cyclin-E1
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0030521 [androgen receptor signaling pathway]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050681 [androgen receptor binding]
GO:0051301 [cell division]
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 395 aa
45.1 kDa 		No 0
CCNE1-004
ENSP00000459024
ENST00000575243
I3L1Q9 [Direct mapping]
G1/S-specific cyclin-E1
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0005654 [nucleoplasm]
GO:0051726 [regulation of cell cycle]
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 216 aa
25.2 kDa 		No 0
CCNE1-005
ENSP00000460881
ENST00000576532
I3L413 [Direct mapping]
G1/S-specific cyclin-E1
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0051726 [regulation of cell cycle]
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 283 aa
32.4 kDa 		No 0
CCNE1-201
ENSP00000350625
ENST00000357943
C9J2U0 [Direct mapping]
Cyclin E variant ex7del; G1/S-specific cyclin-E1
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0005654 [nucleoplasm]
GO:0051726 [regulation of cell cycle]
Show all
 350 aa
39.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.