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A single case each of Hodgkin's lymphoma and stomach cancer along with few cases of squamous cell carcinomas, ovarian and colorectal cancers showed weak to moderate cytoplasmic immunoreactivity. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
EBI3
Synonyms
Description
Epstein-Barr virus induced 3 (HGNC Symbol)
Entrez gene summary
This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the Jak/STAT pathway of CD4+ T cells. [provided by RefSeq, Sep 2008]
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)