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EBI3

GENERAL INFORMATION

Gene name

 EBI3

Gene description

 Epstein-Barr virus induced 3

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (placenta)
GTEx:Tissue enriched (spleen)
FANTOM5:Tissue enriched (placenta)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in placental trophoblasts.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA046635
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (placenta)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (placenta)

GENE INFORMATION

Gene name

 EBI3

Synonyms

Description

 Epstein-Barr virus induced 3 (HGNC Symbol)

Entrez gene summary

 This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the Jak/STAT pathway of CD4+ T cells. [provided by RefSeq, Sep 2008]

Chromosome

 19

Cytoband

 p13.3

Chromosome location (bp)

 4229498 - 4237531

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105246 (version 83.38)

Entrez gene

 10148

UniProt

 Q14213 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14213

Antibodypedia

 EBI3 antibodies

PROTEIN BROWSER
EBI3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EBI3-001
ENSP00000221847
ENST00000221847
Q14213 [Direct mapping]
Interleukin-27 subunit beta
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004896 [cytokine receptor activity]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0006959 [humoral immune response]
GO:0016020 [membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0042088 [T-helper 1 type immune response]
GO:0042098 [T cell proliferation]
GO:0045078 [positive regulation of interferon-gamma biosynthetic process]
GO:0045523 [interleukin-27 receptor binding]
GO:0046641 [positive regulation of alpha-beta T cell proliferation]
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 229 aa
25.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.