Fields »
ABOUT
HELP
BLOG
MTPN

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 MTPN

Gene description

 Myotrophin

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the plasma membrane & cytosol.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (approved), Cytosol (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA019735
SHOW MORE

ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the plasma membrane & cytosol.

Main location

 Plasma membrane (approved), Cytosol (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA019735 A-431 Plasma membrane
Cytosol
HPA019735 U-2 OS Plasma membrane
Mitochondria
Cytosol
HPA019735 U-251 MG Plasma membrane
Cytosol

GENE INFORMATION

Gene name

 MTPN (HGNC Symbol)

Synonyms

 GCDP, MYOTROPHIN, V-1

Description

 Myotrophin (HGNC Symbol)

Entrez gene summary

 The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the 3' end of this transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q33

Chromosome location (bp)

 135926761 - 135977353

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105887 (version 83.38)

Entrez gene

 136319

UniProt

 P58546 (UniProt - Evidence at protein level)

neXtProt

 NX_P58546

Antibodypedia

 MTPN antibodies

PROTEIN BROWSER
MTPN-001
MTPN-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MTPN-001
ENSP00000376800
ENST00000393085
P58546 [Direct mapping]
Myotrophin
Q69YG1 [Target identity:100%; Query identity:100%]
Myotrophin; Myotrophin, isoform CRA_a; Putative uncharacterized protein DKFZp761E1322; V-1 protein; cDNA FLJ31663 fis, clone NT2RI2004504, highly similar to MYOTROPHIN
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006417 [regulation of translation]
GO:0006584 [catecholamine metabolic process]
GO:0008290 [F-actin capping protein complex]
GO:0010557 [positive regulation of macromolecule biosynthetic process]
GO:0010613 [positive regulation of cardiac muscle hypertrophy]
GO:0016049 [cell growth]
GO:0016202 [regulation of striated muscle tissue development]
GO:0021707 [cerebellar granule cell differentiation]
GO:0030182 [neuron differentiation]
GO:0030307 [positive regulation of cell growth]
GO:0030424 [axon]
GO:0043403 [skeletal muscle tissue regeneration]
GO:0043565 [sequence-specific DNA binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051146 [striated muscle cell differentiation]
GO:0051247 [positive regulation of protein metabolic process]
GO:0070062 [extracellular exosome]
GO:0071260 [cellular response to mechanical stimulus]
GO:2000812 [regulation of barbed-end actin filament capping]
Show all
 118 aa
12.9 kDa 		No 0
MTPN-002
ENSP00000388321
ENST00000435723
C9JL85 [Direct mapping]
Myotrophin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 52 aa
5.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.