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Most malignant cells showed weak to moderate cytoplasmic positivity or were negative. A few cases of testicular cancers and malignant melanomas displayed strong positivity. Stomach cancers were negative.
GENE INFORMATION
Gene name
MTPN (HGNC Symbol)
Synonyms
GCDP, MYOTROPHIN, V-1
Description
Myotrophin (HGNC Symbol)
Entrez gene summary
The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the 3' end of this transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease. [provided by RefSeq, Jul 2008]