Cell atlas - CCDC6 - The Human Protein Atlas

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CCDC6

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	CCDC6
Gene description	Coiled-coil domain containing 6
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (supported)
Single-cell variation	Single-cell variation in protein expression observed.
Mouse	Localized to the Cytosol in mouse cells.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA019051
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA019051	A-431	Cytosol
	HPA019051	U-2 OS	Cytosol	Intensity
	HPA019051	U-251 MG	Cytosol	Intensity

MOUSE CELLS

Main location

Cytosol

Mouse gene

ENSMUSG00000048701 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA019051	NIH 3T3	Cytosol

GENE INFORMATION
Gene name	CCDC6 (HGNC Symbol)
Synonyms	D10S170, H4, PTC, TPC, TST1
Description	Coiled-coil domain containing 6 (HGNC Symbol)
Entrez gene summary	This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the ret proto-oncogene is the cause of thyroid papillary carcinoma.[provided by RefSeq, Sep 2010]
Chromosome	10
Cytoband	q21.2
Chromosome location (bp)	59788763 - 59906656
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108091 (version 83.38)
Entrez gene	8030
UniProt	Q16204 (UniProt - Evidence at protein level)
neXtProt	NX_Q16204
Antibodypedia	CCDC6 antibodies

PROTEIN BROWSER

CCDC6-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCDC6-001 ENSP00000263102 ENST00000263102	Q16204 [Direct mapping] Coiled-coil domain-containing protein 6 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0008150 [biological_process] GO:0017124 [SH3 domain binding] Show all	474 aa 53.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.