Expression of CCDC6 in cancer - Summary

GENERAL INFORMATION
Gene name	CCDC6
Gene description	Coiled-coil domain containing 6
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly cytoplasmic expression in several tissue types, most abundant in fallopian tube.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA019049 , HPA019051
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), pancreatic cancer (unfavourable) and head and neck cancer (favourable).
Liver cancer p<0.001 Pancreatic cancer p<0.001 Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA019049	HPA019051

GENE INFORMATION
Gene name	CCDC6 (HGNC Symbol)
Synonyms	D10S170, H4, PTC, TPC, TST1
Description	Coiled-coil domain containing 6 (HGNC Symbol)
Entrez gene summary	This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the ret proto-oncogene is the cause of thyroid papillary carcinoma.[provided by RefSeq, Sep 2010]
Chromosome	10
Cytoband	q21.2
Chromosome location (bp)	59788763 - 59906656
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108091 (version 83.38)
Entrez gene	8030
UniProt	Q16204 (UniProt - Evidence at protein level)
neXtProt	NX_Q16204
Antibodypedia	CCDC6 antibodies

PROTEIN BROWSER

CCDC6-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCDC6-001 ENSP00000263102 ENST00000263102	Q16204 [Direct mapping] Coiled-coil domain-containing protein 6 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0008150 [biological_process] GO:0017124 [SH3 domain binding] Show all	474 aa 53.3 kDa	No	0