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FTSJ3

GENERAL INFORMATION

Gene name

 FTSJ3

Gene description

 FtsJ homolog 3 (E. coli)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nucleolar expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA055544
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA055544

GENE INFORMATION

Gene name

 FTSJ3 (HGNC Symbol)

Synonyms

 SPB1

Description

 FtsJ homolog 3 (E. coli) (HGNC Symbol)

Entrez gene summary

 Although the function of this gene is not known, the existence of this gene is supported by mRNA and EST data. A possible function of the encoded protein can be inferred from amino acid sequence similarity to the E.coli FtsJ protein and to a mouse protein possibly involved in embryogenesis. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q23.3

Chromosome location (bp)

 63819433 - 63830012

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000108592 (version 83.38)

Entrez gene

 117246

UniProt

 Q8IY81 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IY81

Antibodypedia

 FTSJ3 antibodies

PROTEIN BROWSER
FTSJ3-001
FTSJ3-004
FTSJ3-005
FTSJ3-015
FTSJ3-017

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FTSJ3-001
ENSP00000396673
ENST00000427159
Q8IY81 [Direct mapping]
pre-rRNA processing protein FTSJ3
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000453 [enzyme-directed rRNA 2'-O-methylation]
GO:0000463 [maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0000466 [maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0006364 [rRNA processing]
GO:0008168 [methyltransferase activity]
GO:0008650 [rRNA (uridine-2'-O-)-methyltransferase activity]
GO:0016435 [rRNA (guanine) methyltransferase activity]
GO:0030687 [preribosome, large subunit precursor]
GO:0030688 [preribosome, small subunit precursor]
GO:0031167 [rRNA methylation]
GO:0032259 [methylation]
GO:0044822 [poly(A) RNA binding]
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 847 aa
96.6 kDa 		No 0
FTSJ3-004
ENSP00000463229
ENST00000585145
J3QKT6 [Direct mapping]
pre-rRNA-processing protein FTSJ3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 19 aa
2.2 kDa 		No 0
FTSJ3-005
ENSP00000464361
ENST00000584574
J3QRS5 [Direct mapping]
pre-rRNA-processing protein FTSJ3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0008649 [rRNA methyltransferase activity]
GO:0031167 [rRNA methylation]
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 33 aa
3.8 kDa 		No 0
FTSJ3-015
ENSP00000464648
ENST00000581209
J3QSE2 [Direct mapping]
pre-rRNA-processing protein FTSJ3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0008168 [methyltransferase activity]
GO:0008649 [rRNA methyltransferase activity]
GO:0031167 [rRNA methylation]
GO:0032259 [methylation]
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 115 aa
13.1 kDa 		No 0
FTSJ3-017
ENSP00000462290
ENST00000580272
J3KS36 [Direct mapping]
pre-rRNA-processing protein FTSJ3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008168 [methyltransferase activity]
GO:0008649 [rRNA methyltransferase activity]
GO:0031167 [rRNA methylation]
GO:0032259 [methylation]
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 151 aa
16.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.