Cell atlas - PTGES3L-AARSD1 - The Human Protein Atlas

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PTGES3L-AARSD1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nuclear membrane

Human cell
	Cytosol
	Nuclear membrane

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GENERAL INFORMATION
Gene name	PTGES3L-AARSD1
Gene description	PTGES3L-AARSD1 readthrough
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear membrane & cytosol. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Cell line enhanced (THP-1)
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear membrane (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA022869
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (THP-1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear membrane & cytosol. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Nuclear membrane (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA022869	A-431	Nuclear membrane
	HPA022869	A-431	Cytosol
	HPA022869	U-2 OS	Nuclear membrane
	HPA022869	U-2 OS	Cytosol
	HPA022869	U-251 MG	Nuclear membrane
	HPA022869	U-251 MG	Cytosol

GENE INFORMATION
Gene name	PTGES3L-AARSD1
Synonyms
Description	PTGES3L-AARSD1 readthrough (HGNC Symbol)
Entrez gene summary	This locus represents naturally occurring readthrough transcription between the neighboring PTGES3L (prostaglandin E synthase 3 (cytosolic)-like) and AARSD1(alanyl-tRNA synthetase domain containing 1) genes on chromosome 17. The readthrough transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, May 2012]
Chromosome	17
Cytoband	q21.31
Chromosome location (bp)	42950526 - 42980528
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108825 (version 83.38)
Entrez gene	100885850
UniProt	Q9BTE6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BTE6
Antibodypedia	PTGES3L-AARSD1 antibodies

PROTEIN BROWSER

PTGES3L-AARSD1-001	PTGES3L-AARSD1-002	PTGES3L-AARSD1-003	PTGES3L-AARSD1-004	PTGES3L-AARSD1-005	PTGES3L-AARSD1-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PTGES3L-AARSD1-001 ENSP00000409924 ENST00000421990	Q9BTE6 [Direct mapping] Alanyl-tRNA editing protein Aarsd1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000049 [tRNA binding] GO:0000166 [nucleotide binding] GO:0002196 [Ser-tRNA(Ala) hydrolase activity] GO:0003674 [molecular_function] GO:0003676 [nucleic acid binding] GO:0004813 [alanine-tRNA ligase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006419 [alanyl-tRNA aminoacylation] GO:0006450 [regulation of translational fidelity] GO:0008150 [biological_process] GO:0016876 [ligase activity, forming aminoacyl-tRNA and related compounds] GO:0043039 [tRNA aminoacylation] GO:0046872 [metal ion binding] Show all	586 aa 65.7 kDa	No	0
PTGES3L-AARSD1-002 ENSP00000386621 ENST00000409399	Q9BTE6 [Direct mapping] Alanyl-tRNA editing protein Aarsd1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000049 [tRNA binding] GO:0000166 [nucleotide binding] GO:0002196 [Ser-tRNA(Ala) hydrolase activity] GO:0003674 [molecular_function] GO:0003676 [nucleic acid binding] GO:0004813 [alanine-tRNA ligase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006419 [alanyl-tRNA aminoacylation] GO:0006450 [regulation of translational fidelity] GO:0008150 [biological_process] GO:0016876 [ligase activity, forming aminoacyl-tRNA and related compounds] GO:0043039 [tRNA aminoacylation] GO:0046872 [metal ion binding] Show all	586 aa 65.7 kDa	No	0
PTGES3L-AARSD1-003 ENSP00000407951 ENST00000454303	L7N2F6 [Direct mapping] Protein PTGES3L-AARSD1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		132 aa 15.6 kDa	No	0
PTGES3L-AARSD1-004 ENSP00000353355 ENST00000360221	Q9BTE6 [Direct mapping] Alanyl-tRNA editing protein Aarsd1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000049 [tRNA binding] GO:0000166 [nucleotide binding] GO:0002196 [Ser-tRNA(Ala) hydrolase activity] GO:0003674 [molecular_function] GO:0003676 [nucleic acid binding] GO:0004813 [alanine-tRNA ligase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006419 [alanyl-tRNA aminoacylation] GO:0006450 [regulation of translational fidelity] GO:0008150 [biological_process] GO:0016876 [ligase activity, forming aminoacyl-tRNA and related compounds] GO:0043039 [tRNA aminoacylation] GO:0046872 [metal ion binding] Show all	525 aa 58.8 kDa	No	0
PTGES3L-AARSD1-005 ENSP00000386254 ENST00000409103	C9J5N1 [Direct mapping] Protein PTGES3L-AARSD1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0004813 [alanine-tRNA ligase activity] GO:0005524 [ATP binding] GO:0006419 [alanyl-tRNA aminoacylation] GO:0016876 [ligase activity, forming aminoacyl-tRNA and related compounds] GO:0043039 [tRNA aminoacylation] Show all	495 aa 55.1 kDa	No	0
PTGES3L-AARSD1-007 ENSP00000393019 ENST00000452752	H7C054 [Direct mapping] Protein PTGES3L-AARSD1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0004813 [alanine-tRNA ligase activity] GO:0005524 [ATP binding] GO:0006419 [alanyl-tRNA aminoacylation] Show all	189 aa 21.6 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.