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PTGES3L-AARSD1

GENERAL INFORMATION

Gene name

 PTGES3L-AARSD1

Gene description

 PTGES3L-AARSD1 readthrough

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Cell line enhanced (THP-1)
HPA (normal tissue):Tissue enhanced (smooth muscle)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression at variable levels in several cell types. Most abundant in cells in seminiferus ducts.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 3 antibodies.
HPA021408 , HPA022869 , HPA023714
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA021408
HPA022869
HPA023714

GENE INFORMATION

Gene name

 PTGES3L-AARSD1

Synonyms

Description

 PTGES3L-AARSD1 readthrough (HGNC Symbol)

Entrez gene summary

 This locus represents naturally occurring readthrough transcription between the neighboring PTGES3L (prostaglandin E synthase 3 (cytosolic)-like) and AARSD1(alanyl-tRNA synthetase domain containing 1) genes on chromosome 17. The readthrough transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, May 2012]

Chromosome

 17

Cytoband

 q21.31

Chromosome location (bp)

 42950526 - 42980528

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000108825 (version 83.38)

Entrez gene

 100885850

UniProt

 Q9BTE6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BTE6

Antibodypedia

 PTGES3L-AARSD1 antibodies

PROTEIN BROWSER
PTGES3L-AARSD1-001
PTGES3L-AARSD1-002
PTGES3L-AARSD1-003
PTGES3L-AARSD1-004
PTGES3L-AARSD1-005
PTGES3L-AARSD1-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PTGES3L-AARSD1-001
ENSP00000409924
ENST00000421990
Q9BTE6 [Direct mapping]
Alanyl-tRNA editing protein Aarsd1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000049 [tRNA binding]
GO:0000166 [nucleotide binding]
GO:0002196 [Ser-tRNA(Ala) hydrolase activity]
GO:0003674 [molecular_function]
GO:0003676 [nucleic acid binding]
GO:0004813 [alanine-tRNA ligase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006419 [alanyl-tRNA aminoacylation]
GO:0006450 [regulation of translational fidelity]
GO:0008150 [biological_process]
GO:0016876 [ligase activity, forming aminoacyl-tRNA and related compounds]
GO:0043039 [tRNA aminoacylation]
GO:0046872 [metal ion binding]
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 586 aa
65.7 kDa 		No 0
PTGES3L-AARSD1-002
ENSP00000386621
ENST00000409399
Q9BTE6 [Direct mapping]
Alanyl-tRNA editing protein Aarsd1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000049 [tRNA binding]
GO:0000166 [nucleotide binding]
GO:0002196 [Ser-tRNA(Ala) hydrolase activity]
GO:0003674 [molecular_function]
GO:0003676 [nucleic acid binding]
GO:0004813 [alanine-tRNA ligase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006419 [alanyl-tRNA aminoacylation]
GO:0006450 [regulation of translational fidelity]
GO:0008150 [biological_process]
GO:0016876 [ligase activity, forming aminoacyl-tRNA and related compounds]
GO:0043039 [tRNA aminoacylation]
GO:0046872 [metal ion binding]
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 586 aa
65.7 kDa 		No 0
PTGES3L-AARSD1-003
ENSP00000407951
ENST00000454303
L7N2F6 [Direct mapping]
Protein PTGES3L-AARSD1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 132 aa
15.6 kDa 		No 0
PTGES3L-AARSD1-004
ENSP00000353355
ENST00000360221
Q9BTE6 [Direct mapping]
Alanyl-tRNA editing protein Aarsd1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000049 [tRNA binding]
GO:0000166 [nucleotide binding]
GO:0002196 [Ser-tRNA(Ala) hydrolase activity]
GO:0003674 [molecular_function]
GO:0003676 [nucleic acid binding]
GO:0004813 [alanine-tRNA ligase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006419 [alanyl-tRNA aminoacylation]
GO:0006450 [regulation of translational fidelity]
GO:0008150 [biological_process]
GO:0016876 [ligase activity, forming aminoacyl-tRNA and related compounds]
GO:0043039 [tRNA aminoacylation]
GO:0046872 [metal ion binding]
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 525 aa
58.8 kDa 		No 0
PTGES3L-AARSD1-005
ENSP00000386254
ENST00000409103
C9J5N1 [Direct mapping]
Protein PTGES3L-AARSD1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0004813 [alanine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0006419 [alanyl-tRNA aminoacylation]
GO:0016876 [ligase activity, forming aminoacyl-tRNA and related compounds]
GO:0043039 [tRNA aminoacylation]
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 495 aa
55.1 kDa 		No 0
PTGES3L-AARSD1-007
ENSP00000393019
ENST00000452752
H7C054 [Direct mapping]
Protein PTGES3L-AARSD1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0004813 [alanine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0006419 [alanyl-tRNA aminoacylation]
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 189 aa
21.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.