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Solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a sodium/hydrogen exchanger regulatory cofactor. The protein interacts with and regulates various proteins including the cystic fibrosis transmembrane conductance regulator and G-protein coupled receptors such as the beta2-adrenergic receptor and the parathyroid hormone 1 receptor. The protein also interacts with proteins that function as linkers between integral membrane and cytoskeletal proteins. The protein localizes to actin-rich structures including membrane ruffles, microvilli, and filopodia. Mutations in this gene result in hypophosphatemic nephrolithiasis/osteoporosis type 2, and loss of heterozygosity of this gene is implicated in breast cancer.[provided by RefSeq, Sep 2009]
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001726 [ruffle] GO:0003096 [renal sodium ion transport] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005886 [plasma membrane] GO:0005902 [microvillus] GO:0006461 [protein complex assembly] GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway] GO:0007605 [sensory perception of sound] GO:0008013 [beta-catenin binding] GO:0008285 [negative regulation of cell proliferation] GO:0008360 [regulation of cell shape] GO:0008361 [regulation of cell size] GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway] GO:0010766 [negative regulation of sodium ion transport] GO:0012505 [endomembrane system] GO:0014067 [negative regulation of phosphatidylinositol 3-kinase signaling] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0016055 [Wnt signaling pathway] GO:0016324 [apical plasma membrane] GO:0017081 [chloride channel regulator activity] GO:0019902 [phosphatase binding] GO:0019904 [protein domain specific binding] GO:0022612 [gland morphogenesis] GO:0030033 [microvillus assembly] GO:0030036 [actin cytoskeleton organization] GO:0030165 [PDZ domain binding] GO:0030175 [filopodium] GO:0030336 [negative regulation of cell migration] GO:0030643 [cellular phosphate ion homeostasis] GO:0031526 [brush border membrane] GO:0031528 [microvillus membrane] GO:0031698 [beta-2 adrenergic receptor binding] GO:0031982 [vesicle] GO:0032403 [protein complex binding] GO:0032415 [regulation of sodium:proton antiporter activity] GO:0032416 [negative regulation of sodium:proton antiporter activity] GO:0032420 [stereocilium] GO:0032426 [stereocilium bundle tip] GO:0032782 [bile acid secretion] GO:0032947 [protein complex scaffold] GO:0034613 [cellular protein localization] GO:0034635 [glutathione transport] GO:0035414 [negative regulation of catenin import into nucleus] GO:0040023 [establishment of nucleus localization] GO:0043231 [intracellular membrane-bounded organelle] GO:0043621 [protein self-association] GO:0044062 [regulation of excretion] GO:0045121 [membrane raft] GO:0045177 [apical part of cell] GO:0045198 [establishment of epithelial cell apical/basal polarity] GO:0045859 [regulation of protein kinase activity] GO:0045930 [negative regulation of mitotic cell cycle] GO:0048471 [perinuclear region of cytoplasm] GO:0050780 [dopamine receptor binding] GO:0051683 [establishment of Golgi localization] GO:0051898 [negative regulation of protein kinase B signaling] GO:0060088 [auditory receptor cell stereocilium organization] GO:0060158 [phospholipase C-activating dopamine receptor signaling pathway] GO:0070062 [extracellular exosome] GO:0070293 [renal absorption] GO:0070373 [negative regulation of ERK1 and ERK2 cascade] GO:0070851 [growth factor receptor binding] GO:0071944 [cell periphery] GO:0090002 [establishment of protein localization to plasma membrane] GO:0097225 [sperm midpiece] GO:0097291 [renal phosphate ion absorption] GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005886 [plasma membrane] GO:0005902 [microvillus] GO:0006461 [protein complex assembly] GO:0008013 [beta-catenin binding] GO:0008285 [negative regulation of cell proliferation] GO:0008360 [regulation of cell shape] GO:0008361 [regulation of cell size] GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway] GO:0012505 [endomembrane system] GO:0014067 [negative regulation of phosphatidylinositol 3-kinase signaling] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0016055 [Wnt signaling pathway] GO:0016324 [apical plasma membrane] GO:0017081 [chloride channel regulator activity] GO:0019902 [phosphatase binding] GO:0022612 [gland morphogenesis] GO:0030033 [microvillus assembly] GO:0030165 [PDZ domain binding] GO:0030175 [filopodium] GO:0031528 [microvillus membrane] GO:0031698 [beta-2 adrenergic receptor binding] GO:0031982 [vesicle] GO:0032415 [regulation of sodium:proton antiporter activity] GO:0032782 [bile acid secretion] GO:0034635 [glutathione transport] GO:0035414 [negative regulation of catenin import into nucleus] GO:0040023 [establishment of nucleus localization] GO:0043231 [intracellular membrane-bounded organelle] GO:0043621 [protein self-association] GO:0045198 [establishment of epithelial cell apical/basal polarity] GO:0045859 [regulation of protein kinase activity] GO:0045930 [negative regulation of mitotic cell cycle] GO:0048471 [perinuclear region of cytoplasm] GO:0051683 [establishment of Golgi localization] GO:0051898 [negative regulation of protein kinase B signaling] GO:0070062 [extracellular exosome] GO:0070293 [renal absorption] GO:0070373 [negative regulation of ERK1 and ERK2 cascade] GO:0070851 [growth factor receptor binding] GO:0071944 [cell periphery] GO:0090002 [establishment of protein localization to plasma membrane] GO:0097225 [sperm midpiece] GO:0097291 [renal phosphate ion absorption] GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]