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SLC9A3R1
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    TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

SLC9A3R1

Gene description

Solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1

Protein class

Disease related genes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Transporters

Predicted localization

Intracellular

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic and membranous expression in most tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 3 antibodies.
HPA009672 , HPA027247 , CAB001962
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Endometrium

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

SLC9A3R1 (HGNC Symbol)

Synonyms

EBP50, NHERF

Description

Solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a sodium/hydrogen exchanger regulatory cofactor. The protein interacts with and regulates various proteins including the cystic fibrosis transmembrane conductance regulator and G-protein coupled receptors such as the beta2-adrenergic receptor and the parathyroid hormone 1 receptor. The protein also interacts with proteins that function as linkers between integral membrane and cytoskeletal proteins. The protein localizes to actin-rich structures including membrane ruffles, microvilli, and filopodia. Mutations in this gene result in hypophosphatemic nephrolithiasis/osteoporosis type 2, and loss of heterozygosity of this gene is implicated in breast cancer.[provided by RefSeq, Sep 2009]

Chromosome

17

Cytoband

q25.1

Chromosome location (bp)

74748652 - 74769353

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000109062 (version 83.38)

Entrez gene

9368

UniProt

O14745 (UniProt - Evidence at protein level)

neXtProt

NX_O14745

Antibodypedia

SLC9A3R1 antibodies

PROTEIN BROWSER

SLC9A3R1-001
SLC9A3R1-002
SLC9A3R1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SLC9A3R1-001
ENSP00000262613
ENST00000262613
O14745 [Direct mapping]
Na(+)/H(+) exchange regulatory cofactor NHE-RF1
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0003096 [renal sodium ion transport]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005886 [plasma membrane]
GO:0005902 [microvillus]
GO:0006461 [protein complex assembly]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007605 [sensory perception of sound]
GO:0008013 [beta-catenin binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0008361 [regulation of cell size]
GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway]
GO:0010766 [negative regulation of sodium ion transport]
GO:0012505 [endomembrane system]
GO:0014067 [negative regulation of phosphatidylinositol 3-kinase signaling]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016324 [apical plasma membrane]
GO:0017081 [chloride channel regulator activity]
GO:0019902 [phosphatase binding]
GO:0019904 [protein domain specific binding]
GO:0022612 [gland morphogenesis]
GO:0030033 [microvillus assembly]
GO:0030036 [actin cytoskeleton organization]
GO:0030165 [PDZ domain binding]
GO:0030175 [filopodium]
GO:0030336 [negative regulation of cell migration]
GO:0030643 [cellular phosphate ion homeostasis]
GO:0031526 [brush border membrane]
GO:0031528 [microvillus membrane]
GO:0031698 [beta-2 adrenergic receptor binding]
GO:0031982 [vesicle]
GO:0032403 [protein complex binding]
GO:0032415 [regulation of sodium:proton antiporter activity]
GO:0032416 [negative regulation of sodium:proton antiporter activity]
GO:0032420 [stereocilium]
GO:0032426 [stereocilium bundle tip]
GO:0032782 [bile acid secretion]
GO:0032947 [protein complex scaffold]
GO:0034613 [cellular protein localization]
GO:0034635 [glutathione transport]
GO:0035414 [negative regulation of catenin import into nucleus]
GO:0040023 [establishment of nucleus localization]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043621 [protein self-association]
GO:0044062 [regulation of excretion]
GO:0045121 [membrane raft]
GO:0045177 [apical part of cell]
GO:0045198 [establishment of epithelial cell apical/basal polarity]
GO:0045859 [regulation of protein kinase activity]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050780 [dopamine receptor binding]
GO:0051683 [establishment of Golgi localization]
GO:0051898 [negative regulation of protein kinase B signaling]
GO:0060088 [auditory receptor cell stereocilium organization]
GO:0060158 [phospholipase C-activating dopamine receptor signaling pathway]
GO:0070062 [extracellular exosome]
GO:0070293 [renal absorption]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0070851 [growth factor receptor binding]
GO:0071944 [cell periphery]
GO:0090002 [establishment of protein localization to plasma membrane]
GO:0097225 [sperm midpiece]
GO:0097291 [renal phosphate ion absorption]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
358 aa
38.9 kDa
No 0
SLC9A3R1-002
ENSP00000464982
ENST00000413388
O14745 [Direct mapping]
Na(+)/H(+) exchange regulatory cofactor NHE-RF1
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005886 [plasma membrane]
GO:0005902 [microvillus]
GO:0006461 [protein complex assembly]
GO:0008013 [beta-catenin binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0008361 [regulation of cell size]
GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway]
GO:0012505 [endomembrane system]
GO:0014067 [negative regulation of phosphatidylinositol 3-kinase signaling]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016324 [apical plasma membrane]
GO:0017081 [chloride channel regulator activity]
GO:0019902 [phosphatase binding]
GO:0022612 [gland morphogenesis]
GO:0030033 [microvillus assembly]
GO:0030165 [PDZ domain binding]
GO:0030175 [filopodium]
GO:0031528 [microvillus membrane]
GO:0031698 [beta-2 adrenergic receptor binding]
GO:0031982 [vesicle]
GO:0032415 [regulation of sodium:proton antiporter activity]
GO:0032782 [bile acid secretion]
GO:0034635 [glutathione transport]
GO:0035414 [negative regulation of catenin import into nucleus]
GO:0040023 [establishment of nucleus localization]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043621 [protein self-association]
GO:0045198 [establishment of epithelial cell apical/basal polarity]
GO:0045859 [regulation of protein kinase activity]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051683 [establishment of Golgi localization]
GO:0051898 [negative regulation of protein kinase B signaling]
GO:0070062 [extracellular exosome]
GO:0070293 [renal absorption]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0070851 [growth factor receptor binding]
GO:0071944 [cell periphery]
GO:0090002 [establishment of protein localization to plasma membrane]
GO:0097225 [sperm midpiece]
GO:0097291 [renal phosphate ion absorption]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
202 aa
22 kDa
No 0
SLC9A3R1-006
ENSP00000464321
ENST00000583369
J3QRP6 [Direct mapping]
Na(+)/H(+) exchange regulatory cofactor NHE-RF1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0032947 [protein complex scaffold]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
215 aa
22.9 kDa
No 0

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The Human Protein Atlas project is funded
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