Tissue expression of ALDOC - Summary - The Human Protein Atlas

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ALDOC

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TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA
MOUSE BRAIN

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	ALDOC
Gene description	Aldolase C, fructose-bisphosphate
Protein class	Cancer-related genes Candidate cardiovascular disease genes Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (cerebral cortex)
GTEx:	Expressed in all
FANTOM5:	Group enriched (brain, caudate, cerebellum, hippocampus, retina)

Protein evidence

Evidence at protein level

Protein expression

Selective cytoplasmic expression in subsets of neurons and glial cells.

DATA RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA003282 , CAB020828
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (brain, caudate, cerebellum, hippocampus, retina)

GENE INFORMATION
Gene name	ALDOC
Synonyms
Description	Aldolase C, fructose-bisphosphate (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the class I fructose-biphosphate aldolase gene family. Expressed specifically in the hippocampus and Purkinje cells of the brain, the encoded protein is a glycolytic enzyme that catalyzes the reversible aldol cleavage of fructose-1,6-biphosphate and fructose 1-phosphate to dihydroxyacetone phosphate and either glyceraldehyde-3-phosphate or glyceraldehyde, respectively. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q11.2
Chromosome location (bp)	28573115 - 28577264
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000109107 (version 83.38)
Entrez gene	230
UniProt	P09972 (UniProt - Evidence at protein level)
neXtProt	NX_P09972
Antibodypedia	ALDOC antibodies

PROTEIN BROWSER

ALDOC-001	ALDOC-002	ALDOC-003	ALDOC-004	ALDOC-005	ALDOC-006	ALDOC-007	ALDOC-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ALDOC-001 ENSP00000226253 ENST00000226253	P09972 [Direct mapping] Fructose-bisphosphate aldolase C A0A024QZ64 [Target identity:100%; Query identity:100%] Fructose-bisphosphate aldolase Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004332 [fructose-bisphosphate aldolase activity] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005975 [carbohydrate metabolic process] GO:0006000 [fructose metabolic process] GO:0006006 [glucose metabolic process] GO:0006094 [gluconeogenesis] GO:0006096 [glycolytic process] GO:0008092 [cytoskeletal protein binding] GO:0030388 [fructose 1,6-bisphosphate metabolic process] GO:0030855 [epithelial cell differentiation] GO:0044281 [small molecule metabolic process] GO:0061621 [canonical glycolysis] GO:0070062 [extracellular exosome] Show all	364 aa 39.5 kDa	No	0
ALDOC-002 ENSP00000378729 ENST00000395319	A8MVZ9 [Direct mapping] Fructose-bisphosphate aldolase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004332 [fructose-bisphosphate aldolase activity] GO:0006096 [glycolytic process] Show all	336 aa 36.3 kDa	No	0
ALDOC-003 ENSP00000378731 ENST00000395321	P09972 [Direct mapping] Fructose-bisphosphate aldolase C A0A024QZ64 [Target identity:100%; Query identity:100%] Fructose-bisphosphate aldolase Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0004332 [fructose-bisphosphate aldolase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005975 [carbohydrate metabolic process] GO:0006000 [fructose metabolic process] GO:0006006 [glucose metabolic process] GO:0006094 [gluconeogenesis] GO:0006096 [glycolytic process] GO:0008092 [cytoskeletal protein binding] GO:0030388 [fructose 1,6-bisphosphate metabolic process] GO:0030855 [epithelial cell differentiation] GO:0044281 [small molecule metabolic process] GO:0061621 [canonical glycolysis] GO:0070062 [extracellular exosome] Show all	364 aa 39.5 kDa	No	0
ALDOC-004 ENSP00000398976 ENST00000435638	C9J8F3 [Direct mapping] Fructose-bisphosphate aldolase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004332 [fructose-bisphosphate aldolase activity] GO:0006096 [glycolytic process] Show all	149 aa 16.3 kDa	No	0
ALDOC-005 ENSP00000463174 ENST00000460201	J3QKP5 [Direct mapping] Fructose-bisphosphate aldolase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004332 [fructose-bisphosphate aldolase activity] GO:0006096 [glycolytic process] Show all	180 aa 19.7 kDa	No	0
ALDOC-006 ENSP00000462674 ENST00000584086	J3KSV6 [Direct mapping] Fructose-bisphosphate aldolase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004332 [fructose-bisphosphate aldolase activity] GO:0006096 [glycolytic process] Show all	175 aa 19.1 kDa	No	0
ALDOC-007 ENSP00000463118 ENST00000578590	J3QKK1 [Direct mapping] Fructose-bisphosphate aldolase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004332 [fructose-bisphosphate aldolase activity] GO:0006096 [glycolytic process] Show all	122 aa 13.3 kDa	No	0
ALDOC-008 ENSP00000465623 ENST00000581807	K7EKH5 [Direct mapping] Fructose-bisphosphate aldolase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004332 [fructose-bisphosphate aldolase activity] GO:0006096 [glycolytic process] Show all	135 aa 15 kDa	No	0

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