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OSBP

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GENERAL INFORMATION

Gene name

 OSBP

Gene description

 Oxysterol binding protein

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the Golgi apparatus. In addition localized to the nucleus & cytosol.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Golgi apparatus (validated)

Additional location

 In addition localized to the Nucleus (supported), Cytosol (validated)

Mouse

 Localized to the Golgi apparatus, Focal adhesion sites in mouse cells.

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA039227 , HPA043625
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ASSAYS
RNA expression
Human cells
Custom data
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the Golgi apparatus. In addition localized to the nucleus & cytosol.

Main location

 Golgi apparatus (validated)

Additional location

 Nucleus (supported), Cytosol (validated)

 

 

 
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Low
High
G1
S
G2
M
N/A

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Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA039227 A-431 Nucleoplasm
Golgi apparatus
Cell Junctions
Cytosol
HPA039227 U-2 OS Golgi apparatus
HPA039227 U-251 MG Nucleoplasm
Golgi apparatus
Cytosol
HPA043625 A-431 Nucleus
Golgi apparatus
HPA043625 PC-3 Nucleus
Golgi apparatus
HPA043625 U-2 OS Nucleus
Nucleoli
Golgi apparatus

CUSTOM DATA

 

 

 
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Antibody

Cell line

Assay

Description
HPA039227 U-2 OS Image Co-localization with the cis-Golgi marker GM130/GOLGA2 (RRID:AB_398141) for a refined protein localization within the Golgi apparatus in U-2 OS cells. OSBP localizes to the Golgi apparatus, but not to the cis-Golgi compartment.
HPA043625 U-2 OS Image Co-localization with the cis-Golgi marker GM130/GOLGA2 (RRID:AB_398141) for a refined protein localization within the Golgi apparatus in U-2 OS cells. OSBP localizes to the Golgi apparatus, but not to the cis-Golgi compartment.

MOUSE CELLS

Main location

 Golgi apparatus, Focal adhesion sites

Mouse gene

 ENSMUSG00000024687 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA043625 NIH 3T3 Golgi apparatus
Focal adhesion sites

GENE INFORMATION

Gene name

 OSBP (HGNC Symbol)

Synonyms

 OSBP1

Description

 Oxysterol binding protein (HGNC Symbol)

Entrez gene summary

 Oxysterol binding protein is an intracellular protein that is believed to transport sterols from lysosomes to the nucleus where the sterol down-regulates the genes for the LDL receptor, HMG-CoA reductase, and HMG synthetase [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q12.1

Chromosome location (bp)

 59574398 - 59616144

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000110048 (version 83.38)

Entrez gene

 5007

UniProt

 P22059 (UniProt - Evidence at protein level)

neXtProt

 NX_P22059

Antibodypedia

 OSBP antibodies

PROTEIN BROWSER
OSBP-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
OSBP-001
ENSP00000263847
ENST00000263847
P22059 [Direct mapping]
Oxysterol-binding protein 1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0008142 [oxysterol binding]
GO:0015248 [sterol transporter activity]
GO:0015918 [sterol transport]
GO:0016020 [membrane]
GO:0019904 [protein domain specific binding]
GO:0030054 [cell junction]
GO:0044128 [positive regulation of growth of symbiont in host]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070273 [phosphatidylinositol-4-phosphate binding]
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 807 aa
89.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.