Fields »
ABOUT
HELP
BLOG
OSBP

GENERAL INFORMATION

Gene name

 OSBP

Gene description

 Oxysterol binding protein

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA039227 , HPA043625
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and colorectal cancer (favourable).
Renal cancer p<0.001
Colorectal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA039227
HPA043625

GENE INFORMATION

Gene name

 OSBP (HGNC Symbol)

Synonyms

 OSBP1

Description

 Oxysterol binding protein (HGNC Symbol)

Entrez gene summary

 Oxysterol binding protein is an intracellular protein that is believed to transport sterols from lysosomes to the nucleus where the sterol down-regulates the genes for the LDL receptor, HMG-CoA reductase, and HMG synthetase [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q12.1

Chromosome location (bp)

 59574398 - 59616144

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000110048 (version 83.38)

Entrez gene

 5007

UniProt

 P22059 (UniProt - Evidence at protein level)

neXtProt

 NX_P22059

Antibodypedia

 OSBP antibodies

PROTEIN BROWSER
OSBP-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
OSBP-001
ENSP00000263847
ENST00000263847
P22059 [Direct mapping]
Oxysterol-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0008142 [oxysterol binding]
GO:0015248 [sterol transporter activity]
GO:0015918 [sterol transport]
GO:0016020 [membrane]
GO:0019904 [protein domain specific binding]
GO:0030054 [cell junction]
GO:0044128 [positive regulation of growth of symbiont in host]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070273 [phosphatidylinositol-4-phosphate binding]
Show all
 807 aa
89.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.