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OSBP

GENERAL INFORMATION

Gene name

 OSBP

Gene description

 Oxysterol binding protein

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA039227 , HPA043625
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Rectum
N/A
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 OSBP (HGNC Symbol)

Synonyms

 OSBP1

Description

 Oxysterol binding protein (HGNC Symbol)

Entrez gene summary

 Oxysterol binding protein is an intracellular protein that is believed to transport sterols from lysosomes to the nucleus where the sterol down-regulates the genes for the LDL receptor, HMG-CoA reductase, and HMG synthetase [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q12.1

Chromosome location (bp)

 59574398 - 59616144

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000110048 (version 83.38)

Entrez gene

 5007

UniProt

 P22059 (UniProt - Evidence at protein level)

neXtProt

 NX_P22059

Antibodypedia

 OSBP antibodies

PROTEIN BROWSER
OSBP-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
OSBP-001
ENSP00000263847
ENST00000263847
P22059 [Direct mapping]
Oxysterol-binding protein 1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0008142 [oxysterol binding]
GO:0015248 [sterol transporter activity]
GO:0015918 [sterol transport]
GO:0016020 [membrane]
GO:0019904 [protein domain specific binding]
GO:0030054 [cell junction]
GO:0044128 [positive regulation of growth of symbiont in host]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070273 [phosphatidylinositol-4-phosphate binding]
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 807 aa
89.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.