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Most malignant cells exhibited weak to moderate cytoplasmic positivity. Rare cases of pancreatic and thyroid cancers were strongly stained. Most cases of malignant gliomas, testicular, urothelial and cervical cancers were negative.
Malignant tissues displayed moderate to strong cytoplasmic positivity.
GENE INFORMATION
Gene name
UNC93B1 (HGNC Symbol)
Synonyms
UNC93
Description
Unc-93 homolog B1 (C. elegans) (HGNC Symbol)
Entrez gene summary
This gene encodes a protein that is involved in innate and adaptive immune response by regulating toll-like receptor signaling. The encoded protein traffics nucleotide sensing toll-like receptors to the endolysosome from the endoplasmic reticulum. Deficiency of the encoded protein has been associated with herpes simplex encephalitis. [provided by RefSeq, Feb 2014]