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UNC93B1

GENERAL INFORMATION

Gene name

 UNC93B1

Gene description

 Unc-93 homolog B1 (C. elegans)

Protein class

 Disease related genes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA038717 , HPA042803
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Prostate

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 UNC93B1 (HGNC Symbol)

Synonyms

 UNC93

Description

 Unc-93 homolog B1 (C. elegans) (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that is involved in innate and adaptive immune response by regulating toll-like receptor signaling. The encoded protein traffics nucleotide sensing toll-like receptors to the endolysosome from the endoplasmic reticulum. Deficiency of the encoded protein has been associated with herpes simplex encephalitis. [provided by RefSeq, Feb 2014]

Chromosome

 11

Cytoband

 q13.2

Chromosome location (bp)

 67991104 - 68004982

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000110057 (version 83.38)

Entrez gene

 81622

UniProt

 Q9H1C4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H1C4

Antibodypedia

 UNC93B1 antibodies

PROTEIN BROWSER
UNC93B1-001
UNC93B1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UNC93B1-001
ENSP00000227471
ENST00000227471
Q9H1C4 [Direct mapping]
Protein unc-93 homolog B1
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0005764 [lysosome]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006886 [intracellular protein transport]
GO:0016021 [integral component of membrane]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0032009 [early phagosome]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034154 [toll-like receptor 7 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0045087 [innate immune response]
GO:0051607 [defense response to virus]
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 597 aa
66.6 kDa 		No >9
UNC93B1-002
ENSP00000437195
ENST00000528423
E9PNE5 [Direct mapping]
Protein unc-93 homolog B1
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
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 180 aa
21 kDa 		No 4

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.