Cell atlas - FAF2 - The Human Protein Atlas

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FAF2

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum
	Lipid droplets

Human cell
	Endoplasmic Reticulum
	Vesicles

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GENERAL INFORMATION
Gene name	FAF2
Gene description	Fas associated factor family member 2
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the lipid droplets. In addition localized to the endoplasmic reticulum.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Lipid droplets (validated)
Additional location	In addition localized to the Endoplasmic reticulum (supported)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA065968 , HPA073828
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the lipid droplets. In addition localized to the endoplasmic reticulum.

Main location

Lipid droplets (validated)

Additional location

Endoplasmic reticulum (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA065968	MCF7	Lipid droplets
	HPA065968	U-2 OS	Lipid droplets
	HPA065968	U-251 MG	Lipid droplets
	HPA073828	MCF7	Lipid droplets
	HPA073828	RT4	Endoplasmic reticulum
	HPA073828	RT4	Lipid droplets
	HPA073828	U-2 OS	Endoplasmic reticulum
	HPA073828	U-2 OS	Lipid droplets

GENE INFORMATION
Gene name	FAF2 (HGNC Symbol)
Synonyms	ETEA, KIAA0887, UBXD8, UBXN3B
Description	Fas associated factor family member 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is highly expressed in peripheral blood of patients with atopic dermatitis (AD), compared to normal individuals. It may play a role in regulating the resistance to apoptosis that is observed in T cells and eosinophils of AD patients. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q35.2
Chromosome location (bp)	176447628 - 176510074
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000113194 (version 83.38)
Entrez gene	23197
UniProt	Q96CS3 (UniProt - Evidence at protein level)
neXtProt	NX_Q96CS3
Antibodypedia	FAF2 antibodies

PROTEIN BROWSER

FAF2-001	FAF2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FAF2-001 ENSP00000261942 ENST00000261942	Q96CS3 [Direct mapping] FAS-associated factor 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005811 [lipid particle] GO:0006986 [response to unfolded protein] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0030970 [retrograde protein transport, ER to cytosol] GO:0031625 [ubiquitin protein ligase binding] GO:0034098 [VCP-NPL4-UFD1 AAA ATPase complex] GO:0034389 [lipid particle organization] GO:0035473 [lipase binding] GO:0043086 [negative regulation of catalytic activity] GO:0043130 [ubiquitin binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0055102 [lipase inhibitor activity] Show all	445 aa 52.6 kDa	No	1
FAF2-003 ENSP00000424146 ENST00000510730	D6RBG6 [Direct mapping] FAS-associated factor 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		48 aa 5.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.