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FAF2

GENERAL INFORMATION

Gene name

 FAF2

Gene description

 Fas associated factor family member 2

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (unfavourable) and liver cancer (unfavourable).
Lung cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 FAF2 (HGNC Symbol)

Synonyms

 ETEA, KIAA0887, UBXD8, UBXN3B

Description

 Fas associated factor family member 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is highly expressed in peripheral blood of patients with atopic dermatitis (AD), compared to normal individuals. It may play a role in regulating the resistance to apoptosis that is observed in T cells and eosinophils of AD patients. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q35.2

Chromosome location (bp)

 176447628 - 176510074

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000113194 (version 83.38)

Entrez gene

 23197

UniProt

 Q96CS3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96CS3

Antibodypedia

 FAF2 antibodies

PROTEIN BROWSER
FAF2-001
FAF2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FAF2-001
ENSP00000261942
ENST00000261942
Q96CS3 [Direct mapping]
FAS-associated factor 2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005811 [lipid particle]
GO:0006986 [response to unfolded protein]
GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process]
GO:0030970 [retrograde protein transport, ER to cytosol]
GO:0031625 [ubiquitin protein ligase binding]
GO:0034098 [VCP-NPL4-UFD1 AAA ATPase complex]
GO:0034389 [lipid particle organization]
GO:0035473 [lipase binding]
GO:0043086 [negative regulation of catalytic activity]
GO:0043130 [ubiquitin binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0055102 [lipase inhibitor activity]
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 445 aa
52.6 kDa 		No 1
FAF2-003
ENSP00000424146
ENST00000510730
D6RBG6 [Direct mapping]
FAS-associated factor 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 48 aa
5.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.