Fields »
ABOUT
HELP
BLOG
RARS

GENERAL INFORMATION

Gene name

 RARS

Gene description

 Arginyl-tRNA synthetase

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA003979 , HPA004130
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and head and neck cancer (unfavourable).
Liver cancer p<0.001
Head and neck cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA003979
HPA004130

GENE INFORMATION

Gene name

 RARS (HGNC Symbol)

Synonyms

 DALRD1

Description

 Arginyl-tRNA synthetase (HGNC Symbol)

Entrez gene summary

 Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Arginyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q34

Chromosome location (bp)

 168486445 - 168519299

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000113643 (version 83.38)

Entrez gene

 5917

UniProt

 P54136 (UniProt - Evidence at protein level)

neXtProt

 NX_P54136

Antibodypedia

 RARS antibodies

PROTEIN BROWSER
RARS-001
RARS-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RARS-001
ENSP00000231572
ENST00000231572
P54136 [Direct mapping]
Arginine--tRNA ligase, cytoplasmic
Show all
Enzymes
   ENZYME proteins
   Ligase
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000049 [tRNA binding]
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004814 [arginine-tRNA ligase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006420 [arginyl-tRNA aminoacylation]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0017101 [aminoacyl-tRNA synthetase multienzyme complex]
GO:0034618 [arginine binding]
GO:0070062 [extracellular exosome]
Show all
 660 aa
75.4 kDa 		No 0
RARS-201
ENSP00000486284
ENST00000626454
E5RI24 [Direct mapping]
Arginine--tRNA ligase, cytoplasmic
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004814 [arginine-tRNA ligase activity]
Show all
 58 aa
6.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.