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TCERG1

GENERAL INFORMATION

Gene name

 TCERG1

Gene description

 Transcription elongation regulator 1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA064854
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Renal cancer

STAINING SUMMARY
HPA064854

GENE INFORMATION

Gene name

 TCERG1 (HGNC Symbol)

Synonyms

 CA150, TAF2S, Urn1

Description

 Transcription elongation regulator 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q32

Chromosome location (bp)

 146447311 - 146511961

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000113649 (version 83.38)

Entrez gene

 10915

UniProt

 O14776 (UniProt - Evidence at protein level)

neXtProt

 NX_O14776

Antibodypedia

 TCERG1 antibodies

PROTEIN BROWSER
TCERG1-001
TCERG1-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TCERG1-001
ENSP00000296702
ENST00000296702
O14776 [Direct mapping]
Transcription elongation regulator 1
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001103 [RNA polymerase II repressing transcription factor binding]
GO:0001106 [RNA polymerase II transcription corepressor activity]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0015629 [actin cytoskeleton]
GO:0044822 [poly(A) RNA binding]
GO:0070064 [proline-rich region binding]
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 1098 aa
123.9 kDa 		No 0
TCERG1-007
ENSP00000377943
ENST00000394421
O14776 [Direct mapping]
Transcription elongation regulator 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001103 [RNA polymerase II repressing transcription factor binding]
GO:0001106 [RNA polymerase II transcription corepressor activity]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0015629 [actin cytoskeleton]
GO:0044822 [poly(A) RNA binding]
Show all
 1077 aa
121.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.