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CDX1

GENERAL INFORMATION

Gene name

 CDX1

Gene description

 Caudal type homeobox 1

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (colon, duodenum, rectum, small intestine)
GTEx:Group enriched (colon, small intestine)
FANTOM5:Group enriched (appendix, colon, small intestine)

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in intestinal epithelium

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Caution, Splice and/or transcript discrepancy exists.

Reliability score

 Supported based on 1 antibody.
HPA055196
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Rectum

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (colon, duodenum, rectum, small intestine)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (colon, small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (appendix, colon, small intestine)

GENE INFORMATION

Gene name

 CDX1

Synonyms

Description

 Caudal type homeobox 1 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded DNA-binding protein regulates intestine-specific gene expression and enterocyte differentiation. It has been shown to induce expression of the intestinal alkaline phosphatase gene, and inhibit beta-catenin/T-cell factor transcriptional activity. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q32

Chromosome location (bp)

 150166795 - 150184558

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000113722 (version 83.38)

Entrez gene

 1044

UniProt

 P47902 (UniProt - Evidence at protein level)

neXtProt

 NX_P47902

Antibodypedia

 CDX1 antibodies

PROTEIN BROWSER
CDX1-001
CDX1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDX1-001
ENSP00000231656
ENST00000231656
P47902 [Direct mapping]
Homeobox protein CDX-1
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
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GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007275 [multicellular organismal development]
GO:0007389 [pattern specification process]
GO:0009887 [organ morphogenesis]
GO:0009948 [anterior/posterior axis specification]
GO:0009952 [anterior/posterior pattern specification]
GO:0014807 [regulation of somitogenesis]
GO:0030154 [cell differentiation]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0060349 [bone morphogenesis]
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 265 aa
28.1 kDa 		No 0
CDX1-201
ENSP00000477928
ENST00000616154
A0A087WTJ6 [Direct mapping]
Homeobox protein CDX-1
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Predicted intracellular proteins
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
Show all
 154 aa
17.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.