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The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Translocations
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0005515 [protein binding] GO:0042092 [type 2 immune response] GO:0042127 [regulation of cell proliferation] GO:0045595 [regulation of cell differentiation] GO:0050727 [regulation of inflammatory response]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Translocations
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0005515 [protein binding] GO:0042092 [type 2 immune response] GO:0042127 [regulation of cell proliferation] GO:0045595 [regulation of cell differentiation] GO:0050727 [regulation of inflammatory response]