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BCL6

GENERAL INFORMATION

Gene name

 BCL6

Gene description

 B-cell CLL/lymphoma 6

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (Daudi, U-698)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression, mainly in lymphoid tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA004899 , CAB000307
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Lymphoma

STAINING SUMMARY
HPA004899
CAB000307

GENE INFORMATION

Gene name

 BCL6 (HGNC Symbol)

Synonyms

 BCL5, BCL6A, LAZ3, ZBTB27, ZNF51

Description

 B-cell CLL/lymphoma 6 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

Chromosome

 3

Cytoband

 q27.3

Chromosome location (bp)

 187721377 - 187745727

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000113916 (version 83.38)

Entrez gene

 604

UniProt

 P41182 (UniProt - Evidence at protein level)

neXtProt

 NX_P41182

Antibodypedia

 BCL6 antibodies

PROTEIN BROWSER
BCL6-001
BCL6-004
BCL6-007
BCL6-008
BCL6-010
BCL6-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BCL6-001
ENSP00000384371
ENST00000406870
P41182 [Direct mapping]
B-cell lymphoma 6 protein
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Disease related genes
Show all
GO:0000060 [protein import into nucleus, translocation]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000902 [cell morphogenesis]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001161 [intronic transcription regulatory region sequence-specific DNA binding]
GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001953 [negative regulation of cell-matrix adhesion]
GO:0002467 [germinal center formation]
GO:0002634 [regulation of germinal center formation]
GO:0002829 [negative regulation of type 2 immune response]
GO:0002903 [negative regulation of B cell apoptotic process]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005657 [replication fork]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006954 [inflammatory response]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007266 [Rho protein signal transduction]
GO:0007283 [spermatogenesis]
GO:0008104 [protein localization]
GO:0008285 [negative regulation of cell proliferation]
GO:0030036 [actin cytoskeleton organization]
GO:0030183 [B cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0030890 [positive regulation of B cell proliferation]
GO:0031065 [positive regulation of histone deacetylation]
GO:0031490 [chromatin DNA binding]
GO:0032764 [negative regulation of mast cell cytokine production]
GO:0035024 [negative regulation of Rho protein signal transduction]
GO:0042092 [type 2 immune response]
GO:0042127 [regulation of cell proliferation]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043087 [regulation of GTPase activity]
GO:0043380 [regulation of memory T cell differentiation]
GO:0043565 [sequence-specific DNA binding]
GO:0045595 [regulation of cell differentiation]
GO:0045596 [negative regulation of cell differentiation]
GO:0045629 [negative regulation of T-helper 2 cell differentiation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045746 [negative regulation of Notch signaling pathway]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0048294 [negative regulation of isotype switching to IgE isotypes]
GO:0048821 [erythrocyte development]
GO:0050727 [regulation of inflammatory response]
GO:0050776 [regulation of immune response]
GO:0051272 [positive regulation of cellular component movement]
GO:2000773 [negative regulation of cellular senescence]
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 706 aa
78.8 kDa 		No 0
BCL6-004
ENSP00000232014
ENST00000232014
P41182 [Direct mapping]
B-cell lymphoma 6 protein
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Disease related genes
Show all
GO:0000060 [protein import into nucleus, translocation]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0002634 [regulation of germinal center formation]
GO:0002903 [negative regulation of B cell apoptotic process]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005657 [replication fork]
GO:0006351 [transcription, DNA-templated]
GO:0006954 [inflammatory response]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0030308 [negative regulation of cell growth]
GO:0042092 [type 2 immune response]
GO:0042127 [regulation of cell proliferation]
GO:0043065 [positive regulation of apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0045595 [regulation of cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0050727 [regulation of inflammatory response]
GO:0050776 [regulation of immune response]
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 706 aa
78.8 kDa 		No 0
BCL6-007
ENSP00000414455
ENST00000438077
C9JL16 [Direct mapping]
B-cell lymphoma 6 protein
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0005515 [protein binding]
GO:0042092 [type 2 immune response]
GO:0042127 [regulation of cell proliferation]
GO:0045595 [regulation of cell differentiation]
GO:0050727 [regulation of inflammatory response]
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 104 aa
11.8 kDa 		No 0
BCL6-008
ENSP00000415574
ENST00000430339
C9JCS5 [Direct mapping]
B-cell lymphoma 6 protein
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0005515 [protein binding]
GO:0042092 [type 2 immune response]
GO:0042127 [regulation of cell proliferation]
GO:0045595 [regulation of cell differentiation]
GO:0050727 [regulation of inflammatory response]
Show all
 122 aa
13.9 kDa 		No 0
BCL6-010
ENSP00000413122
ENST00000450123
P41182 [Direct mapping]
B-cell lymphoma 6 protein
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Disease related genes
Show all
GO:0000060 [protein import into nucleus, translocation]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0002634 [regulation of germinal center formation]
GO:0002903 [negative regulation of B cell apoptotic process]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005657 [replication fork]
GO:0006351 [transcription, DNA-templated]
GO:0006954 [inflammatory response]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0030308 [negative regulation of cell growth]
GO:0042092 [type 2 immune response]
GO:0042127 [regulation of cell proliferation]
GO:0043065 [positive regulation of apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0045595 [regulation of cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0050727 [regulation of inflammatory response]
GO:0050776 [regulation of immune response]
Show all
 650 aa
72.4 kDa 		No 0
BCL6-201
ENSP00000479784
ENST00000621333
P41182 [Direct mapping]
B-cell lymphoma 6 protein
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Disease related genes
Show all
GO:0000060 [protein import into nucleus, translocation]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0002634 [regulation of germinal center formation]
GO:0002903 [negative regulation of B cell apoptotic process]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005657 [replication fork]
GO:0006351 [transcription, DNA-templated]
GO:0006954 [inflammatory response]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0030308 [negative regulation of cell growth]
GO:0042092 [type 2 immune response]
GO:0042127 [regulation of cell proliferation]
GO:0043065 [positive regulation of apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0045595 [regulation of cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0050727 [regulation of inflammatory response]
GO:0050776 [regulation of immune response]
Show all
 650 aa
72.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.