We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
A majority of tumour tissues were negative or displayed weak nuclear staining. Moderate immunoreactivity was observed in gliomas, lymphomas, melanomas and prostate cancers.
GENE INFORMATION
Gene name
KAT2B (HGNC Symbol)
Synonyms
GCN5, GCN5L, P/CAF, PCAF
Description
K(lysine) acetyltransferase 2B (HGNC Symbol)
Entrez gene summary
CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Transferases SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000123 [histone acetyltransferase complex] GO:0000125 [PCAF complex] GO:0000776 [kinetochore] GO:0000790 [nuclear chromatin] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0003682 [chromatin binding] GO:0003712 [transcription cofactor activity] GO:0003713 [transcription coactivator activity] GO:0004402 [histone acetyltransferase activity] GO:0004468 [lysine N-acetyltransferase activity, acting on acetyl phosphate as donor] GO:0004861 [cyclin-dependent protein serine/threonine kinase inhibitor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005671 [Ada2/Gcn5/Ada3 transcription activator complex] GO:0005829 [cytosol] GO:0006325 [chromatin organization] GO:0006338 [chromatin remodeling] GO:0006355 [regulation of transcription, DNA-templated] GO:0006360 [transcription from RNA polymerase I promoter] GO:0006361 [transcription initiation from RNA polymerase I promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006473 [protein acetylation] GO:0007050 [cell cycle arrest] GO:0007219 [Notch signaling pathway] GO:0007613 [memory] GO:0008080 [N-acetyltransferase activity] GO:0008134 [transcription factor binding] GO:0008285 [negative regulation of cell proliferation] GO:0010467 [gene expression] GO:0010835 [regulation of protein ADP-ribosylation] GO:0010976 [positive regulation of neuron projection development] GO:0016032 [viral process] GO:0016407 [acetyltransferase activity] GO:0016573 [histone acetylation] GO:0018076 [N-terminal peptidyl-lysine acetylation] GO:0018393 [internal peptidyl-lysine acetylation] GO:0018394 [peptidyl-lysine acetylation] GO:0019901 [protein kinase binding] GO:0031672 [A band] GO:0031674 [I band] GO:0032403 [protein complex binding] GO:0032869 [cellular response to insulin stimulus] GO:0034599 [cellular response to oxidative stress] GO:0035035 [histone acetyltransferase binding] GO:0035563 [positive regulation of chromatin binding] GO:0035948 [positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter] GO:0042641 [actomyosin] GO:0042826 [histone deacetylase binding] GO:0043966 [histone H3 acetylation] GO:0043970 [histone H3-K9 acetylation] GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045909 [positive regulation of vasodilation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048511 [rhythmic process] GO:0071374 [cellular response to parathyroid hormone stimulus] GO:0071442 [positive regulation of histone H3-K14 acetylation] GO:2000617 [positive regulation of histone H3-K9 acetylation]