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CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Transferases SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000123 [histone acetyltransferase complex] GO:0000125 [PCAF complex] GO:0000776 [kinetochore] GO:0000790 [nuclear chromatin] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0003682 [chromatin binding] GO:0003712 [transcription cofactor activity] GO:0003713 [transcription coactivator activity] GO:0004402 [histone acetyltransferase activity] GO:0004468 [lysine N-acetyltransferase activity, acting on acetyl phosphate as donor] GO:0004861 [cyclin-dependent protein serine/threonine kinase inhibitor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005671 [Ada2/Gcn5/Ada3 transcription activator complex] GO:0005829 [cytosol] GO:0006325 [chromatin organization] GO:0006338 [chromatin remodeling] GO:0006355 [regulation of transcription, DNA-templated] GO:0006360 [transcription from RNA polymerase I promoter] GO:0006361 [transcription initiation from RNA polymerase I promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006473 [protein acetylation] GO:0007050 [cell cycle arrest] GO:0007219 [Notch signaling pathway] GO:0007613 [memory] GO:0008080 [N-acetyltransferase activity] GO:0008134 [transcription factor binding] GO:0008285 [negative regulation of cell proliferation] GO:0010467 [gene expression] GO:0010835 [regulation of protein ADP-ribosylation] GO:0010976 [positive regulation of neuron projection development] GO:0016032 [viral process] GO:0016407 [acetyltransferase activity] GO:0016573 [histone acetylation] GO:0018076 [N-terminal peptidyl-lysine acetylation] GO:0018393 [internal peptidyl-lysine acetylation] GO:0018394 [peptidyl-lysine acetylation] GO:0019901 [protein kinase binding] GO:0031672 [A band] GO:0031674 [I band] GO:0032403 [protein complex binding] GO:0032869 [cellular response to insulin stimulus] GO:0034599 [cellular response to oxidative stress] GO:0035035 [histone acetyltransferase binding] GO:0035563 [positive regulation of chromatin binding] GO:0035948 [positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter] GO:0042641 [actomyosin] GO:0042826 [histone deacetylase binding] GO:0043966 [histone H3 acetylation] GO:0043970 [histone H3-K9 acetylation] GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045909 [positive regulation of vasodilation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048511 [rhythmic process] GO:0071374 [cellular response to parathyroid hormone stimulus] GO:0071442 [positive regulation of histone H3-K14 acetylation] GO:2000617 [positive regulation of histone H3-K9 acetylation]