Cell atlas - ABCC5 - The Human Protein Atlas

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ABCC5

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cell Junctions
	Nucleus
	Plasma membrane

Human cell
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	ABCC5
Gene description	ATP-binding cassette, sub-family C (CFTR/MRP), member 5
Protein class	Cancer-related genes Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane. In addition localized to the nucleus & cell junctions.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (supported)
Additional location	In addition localized to the Nucleus (approved), Cell Junctions (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA044067
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane. In addition localized to the nucleus & cell junctions.

Main location

Plasma membrane (supported)

Additional location

Nucleus (approved), Cell Junctions (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA044067	MCF7	Nucleus
			Plasma membrane
			Cell Junctions
	HPA044067	RT4	Nucleoplasm
			Plasma membrane
			Cell Junctions

GENE INFORMATION
Gene name	ABCC5 (HGNC Symbol)
Synonyms	EST277145, MOAT-C, MRP5, SMRP
Description	ATP-binding cassette, sub-family C (CFTR/MRP), member 5 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	q27.1
Chromosome location (bp)	183919934 - 184018015
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000114770 (version 83.38)
Entrez gene	10057
UniProt	O15440 (UniProt - Evidence at protein level)
neXtProt	NX_O15440
Antibodypedia	ABCC5 antibodies

PROTEIN BROWSER

ABCC5-001	ABCC5-002	ABCC5-004	ABCC5-005	ABCC5-006	ABCC5-010	ABCC5-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ABCC5-001 ENSP00000333926 ENST00000334444	O15440 [Direct mapping] Multidrug resistance-associated protein 5 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0006810 [transport] GO:0008514 [organic anion transmembrane transporter activity] GO:0015711 [organic anion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0030203 [glycosaminoglycan metabolic process] GO:0030212 [hyaluronan metabolic process] GO:0030213 [hyaluronan biosynthetic process] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0044281 [small molecule metabolic process] GO:0055085 [transmembrane transport] Show all	1437 aa 160.7 kDa	No	>9
ABCC5-002 ENSP00000390911 ENST00000446941	E9PET4 [Direct mapping] Multidrug resistance-associated protein 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		53 aa 6.2 kDa	No	0
ABCC5-004 ENSP00000376358 ENST00000392579	O15440 [Direct mapping] Multidrug resistance-associated protein 5 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0006810 [transport] GO:0008514 [organic anion transmembrane transporter activity] GO:0015711 [organic anion transport] GO:0016020 [membrane] GO:0030203 [glycosaminoglycan metabolic process] GO:0030212 [hyaluronan metabolic process] GO:0030213 [hyaluronan biosynthetic process] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0044281 [small molecule metabolic process] GO:0055085 [transmembrane transport] Show all	225 aa 25.3 kDa	No	1
ABCC5-005 ENSP00000371934 ENST00000382494	O15440 [Direct mapping] Multidrug resistance-associated protein 5 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0006810 [transport] GO:0008514 [organic anion transmembrane transporter activity] GO:0015711 [organic anion transport] GO:0016020 [membrane] GO:0030203 [glycosaminoglycan metabolic process] GO:0030212 [hyaluronan metabolic process] GO:0030213 [hyaluronan biosynthetic process] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0044281 [small molecule metabolic process] GO:0055085 [transmembrane transport] Show all	208 aa 23.7 kDa	No	1
ABCC5-006 ENSP00000404809 ENST00000427120	A5PKY6 [Direct mapping] ABCC5 protein; Multidrug resistance-associated protein 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0008514 [organic anion transmembrane transporter activity] GO:0015711 [organic anion transport] GO:0016021 [integral component of membrane] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0055085 [transmembrane transport] Show all	231 aa 26.2 kDa	No	1
ABCC5-010 ENSP00000399726 ENST00000437341	C9JZL5 [Direct mapping] Multidrug resistance-associated protein 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0008514 [organic anion transmembrane transporter activity] GO:0015711 [organic anion transport] GO:0016021 [integral component of membrane] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0055085 [transmembrane transport] Show all	147 aa 16.7 kDa	No	0
ABCC5-201 ENSP00000265586 ENST00000265586	O15440 [Direct mapping] Multidrug resistance-associated protein 5 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0006810 [transport] GO:0008514 [organic anion transmembrane transporter activity] GO:0015711 [organic anion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0030203 [glycosaminoglycan metabolic process] GO:0030212 [hyaluronan metabolic process] GO:0030213 [hyaluronan biosynthetic process] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0044281 [small molecule metabolic process] GO:0055085 [transmembrane transport] Show all	1394 aa 155.7 kDa	No	>9

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.