Expression of ABCC5 in cancer - Summary - The Human Protein Atlas

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ABCC5

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ABCC5
Gene description	ATP-binding cassette, sub-family C (CFTR/MRP), member 5
Protein class	Cancer-related genes Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending retesting.
Reliability score	Uncertain based on 1 antibody. HPA052295
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and prostate cancer (unfavourable).
Liver cancer p<0.001 Prostate cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA052295

GENE INFORMATION
Gene name	ABCC5 (HGNC Symbol)
Synonyms	EST277145, MOAT-C, MRP5, SMRP
Description	ATP-binding cassette, sub-family C (CFTR/MRP), member 5 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	q27.1
Chromosome location (bp)	183919934 - 184018015
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000114770 (version 83.38)
Entrez gene	10057
UniProt	O15440 (UniProt - Evidence at protein level)
neXtProt	NX_O15440
Antibodypedia	ABCC5 antibodies

PROTEIN BROWSER

ABCC5-001	ABCC5-002	ABCC5-004	ABCC5-005	ABCC5-006	ABCC5-010	ABCC5-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ABCC5-001 ENSP00000333926 ENST00000334444	O15440 [Direct mapping] Multidrug resistance-associated protein 5 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0006810 [transport] GO:0008514 [organic anion transmembrane transporter activity] GO:0015711 [organic anion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0030203 [glycosaminoglycan metabolic process] GO:0030212 [hyaluronan metabolic process] GO:0030213 [hyaluronan biosynthetic process] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0044281 [small molecule metabolic process] GO:0055085 [transmembrane transport] Show all	1437 aa 160.7 kDa	No	>9
ABCC5-002 ENSP00000390911 ENST00000446941	E9PET4 [Direct mapping] Multidrug resistance-associated protein 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		53 aa 6.2 kDa	No	0
ABCC5-004 ENSP00000376358 ENST00000392579	O15440 [Direct mapping] Multidrug resistance-associated protein 5 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0006810 [transport] GO:0008514 [organic anion transmembrane transporter activity] GO:0015711 [organic anion transport] GO:0016020 [membrane] GO:0030203 [glycosaminoglycan metabolic process] GO:0030212 [hyaluronan metabolic process] GO:0030213 [hyaluronan biosynthetic process] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0044281 [small molecule metabolic process] GO:0055085 [transmembrane transport] Show all	225 aa 25.3 kDa	No	1
ABCC5-005 ENSP00000371934 ENST00000382494	O15440 [Direct mapping] Multidrug resistance-associated protein 5 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0006810 [transport] GO:0008514 [organic anion transmembrane transporter activity] GO:0015711 [organic anion transport] GO:0016020 [membrane] GO:0030203 [glycosaminoglycan metabolic process] GO:0030212 [hyaluronan metabolic process] GO:0030213 [hyaluronan biosynthetic process] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0044281 [small molecule metabolic process] GO:0055085 [transmembrane transport] Show all	208 aa 23.7 kDa	No	1
ABCC5-006 ENSP00000404809 ENST00000427120	A5PKY6 [Direct mapping] ABCC5 protein; Multidrug resistance-associated protein 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0008514 [organic anion transmembrane transporter activity] GO:0015711 [organic anion transport] GO:0016021 [integral component of membrane] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0055085 [transmembrane transport] Show all	231 aa 26.2 kDa	No	1
ABCC5-010 ENSP00000399726 ENST00000437341	C9JZL5 [Direct mapping] Multidrug resistance-associated protein 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0008514 [organic anion transmembrane transporter activity] GO:0015711 [organic anion transport] GO:0016021 [integral component of membrane] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0055085 [transmembrane transport] Show all	147 aa 16.7 kDa	No	0
ABCC5-201 ENSP00000265586 ENST00000265586	O15440 [Direct mapping] Multidrug resistance-associated protein 5 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0006810 [transport] GO:0008514 [organic anion transmembrane transporter activity] GO:0015711 [organic anion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0030203 [glycosaminoglycan metabolic process] GO:0030212 [hyaluronan metabolic process] GO:0030213 [hyaluronan biosynthetic process] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0044281 [small molecule metabolic process] GO:0055085 [transmembrane transport] Show all	1394 aa 155.7 kDa	No	>9

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