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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ABCC5
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ABCC5

Gene description

ATP-binding cassette, sub-family C (CFTR/MRP), member 5

Protein class

Cancer-related genes
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

Intracellular,Membrane

Number of transcripts

7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Pending retesting.

Reliability score

Uncertain based on 1 antibody.
HPA052295
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in liver cancer (unfavourable) and prostate cancer (unfavourable).
Liver cancer p<0.001
Prostate cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Glioma

STAINING SUMMARY

HPA052295

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Weak to moderate cytoplasmic and/or occasional membranous immunoreactivity was observed in several thyroid cancers and a rare case of urothelial cancer. A few cases of high grade malignant gliomas showed moderate to strong cytoplasmic staining. Remaining malignant tissues were negative.

GENE INFORMATION

Gene name

ABCC5 (HGNC Symbol)

Synonyms

EST277145, MOAT-C, MRP5, SMRP

Description

ATP-binding cassette, sub-family C (CFTR/MRP), member 5 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear. [provided by RefSeq, Jul 2008]

Chromosome

3

Cytoband

q27.1

Chromosome location (bp)

183919934 - 184018015

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000114770 (version 83.38)

Entrez gene

10057

UniProt

O15440 (UniProt - Evidence at protein level)

neXtProt

NX_O15440

Antibodypedia

ABCC5 antibodies

PROTEIN BROWSER

ABCC5-001
ABCC5-002
ABCC5-004
ABCC5-005
ABCC5-006
ABCC5-010
ABCC5-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ABCC5-001
ENSP00000333926
ENST00000334444
O15440 [Direct mapping]
Multidrug resistance-associated protein 5
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006810 [transport]
GO:0008514 [organic anion transmembrane transporter activity]
GO:0015711 [organic anion transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030213 [hyaluronan biosynthetic process]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0044281 [small molecule metabolic process]
GO:0055085 [transmembrane transport]
Show all
1437 aa
160.7 kDa
No >9
ABCC5-002
ENSP00000390911
ENST00000446941
E9PET4 [Direct mapping]
Multidrug resistance-associated protein 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
53 aa
6.2 kDa
No 0
ABCC5-004
ENSP00000376358
ENST00000392579
O15440 [Direct mapping]
Multidrug resistance-associated protein 5
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006810 [transport]
GO:0008514 [organic anion transmembrane transporter activity]
GO:0015711 [organic anion transport]
GO:0016020 [membrane]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030213 [hyaluronan biosynthetic process]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0044281 [small molecule metabolic process]
GO:0055085 [transmembrane transport]
Show all
225 aa
25.3 kDa
No 1
ABCC5-005
ENSP00000371934
ENST00000382494
O15440 [Direct mapping]
Multidrug resistance-associated protein 5
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006810 [transport]
GO:0008514 [organic anion transmembrane transporter activity]
GO:0015711 [organic anion transport]
GO:0016020 [membrane]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030213 [hyaluronan biosynthetic process]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0044281 [small molecule metabolic process]
GO:0055085 [transmembrane transport]
Show all
208 aa
23.7 kDa
No 1
ABCC5-006
ENSP00000404809
ENST00000427120
A5PKY6 [Direct mapping]
ABCC5 protein; Multidrug resistance-associated protein 5
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0008514 [organic anion transmembrane transporter activity]
GO:0015711 [organic anion transport]
GO:0016021 [integral component of membrane]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
Show all
231 aa
26.2 kDa
No 1
ABCC5-010
ENSP00000399726
ENST00000437341
C9JZL5 [Direct mapping]
Multidrug resistance-associated protein 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0008514 [organic anion transmembrane transporter activity]
GO:0015711 [organic anion transport]
GO:0016021 [integral component of membrane]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
Show all
147 aa
16.7 kDa
No 0
ABCC5-201
ENSP00000265586
ENST00000265586
O15440 [Direct mapping]
Multidrug resistance-associated protein 5
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006810 [transport]
GO:0008514 [organic anion transmembrane transporter activity]
GO:0015711 [organic anion transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030213 [hyaluronan biosynthetic process]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0044281 [small molecule metabolic process]
GO:0055085 [transmembrane transport]
Show all
1394 aa
155.7 kDa
No >9

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.