Expression of AADAC in cancer - Summary

GENERAL INFORMATION
Gene name	AADAC
Gene description	Arylacetamide deacetylase
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (liver cancer)
HPA (cell line):	Cell line enhanced (A549, EFO-21)
HPA (normal tissue):	Group enriched (adrenal gland, duodenum, liver, small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, most adundant in liver, small intestines and adrenal gland.

ANTIBODY IHC RELIABILITY
Data reliability description	Nuclear staining was seen as off target and disregarded.
Reliability score	Approved based on 1 antibody. HPA002911
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PROGNOSTIC SUMMARY
Prognostic marker in ovarian cancer (favourable), stomach cancer (unfavourable) and pancreatic cancer (unfavourable).
Ovarian cancer p<0.001 Stomach cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA002911

GENE INFORMATION
Gene name	AADAC (HGNC Symbol)
Synonyms	CES5A1, DAC
Description	Arylacetamide deacetylase (HGNC Symbol)
Entrez gene summary	Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	q25.1
Chromosome location (bp)	151814037 - 151828488
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000114771 (version 83.38)
Entrez gene	13
UniProt	P22760 (UniProt - Evidence at protein level)
neXtProt	NX_P22760
Antibodypedia	AADAC antibodies

PROTEIN BROWSER

AADAC-001	AADAC-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AADAC-001 ENSP00000232892 ENST00000232892	P22760 [Direct mapping] Arylacetamide deacetylase Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004806 [triglyceride lipase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006805 [xenobiotic metabolic process] GO:0008152 [metabolic process] GO:0010898 [positive regulation of triglyceride catabolic process] GO:0016021 [integral component of membrane] GO:0016298 [lipase activity] GO:0016787 [hydrolase activity] GO:0017171 [serine hydrolase activity] GO:0019213 [deacetylase activity] GO:0044281 [small molecule metabolic process] GO:0052689 [carboxylic ester hydrolase activity] Show all	399 aa 45.7 kDa	No	0
AADAC-002 ENSP00000419620 ENST00000488869	C9K0E9 [Direct mapping] Arylacetamide deacetylase Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016787 [hydrolase activity] Show all	204 aa 23.1 kDa	No	0