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Term
Gene name

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Chromosome

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In atlas

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Reliability

Reliability

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Method

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Method

Validation

Method

Validation

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Searches

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Specificity

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Cancer

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Detectable

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Detectable

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AADAC
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

AADAC

Gene description

Arylacetamide deacetylase

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Group enriched (adrenal gland, duodenum, liver, small intestine)
GTEx:Group enriched (adrenal gland, liver)
FANTOM5:Group enriched (colon, liver, pancreas, small intestine)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues, most adundant in liver, small intestines and adrenal gland.

DATA RELIABILITY

Data reliability
description

Nuclear staining was seen as off target and disregarded.

Reliability score

Approved based on 1 antibody.
HPA002911
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
N/A
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Duodenum

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (adrenal gland, duodenum, liver, small intestine)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (adrenal gland, liver)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (colon, liver, pancreas, small intestine)

GENE INFORMATION

Gene name

AADAC (HGNC Symbol)

Synonyms

CES5A1, DAC

Description

Arylacetamide deacetylase (HGNC Symbol)

Entrez gene summary

Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens [provided by RefSeq, Jul 2008]

Chromosome

3

Cytoband

q25.1

Chromosome location (bp)

151814037 - 151828488

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000114771 (version 83.38)

Entrez gene

13

UniProt

P22760 (UniProt - Evidence at protein level)

neXtProt

NX_P22760

Antibodypedia

AADAC antibodies

PROTEIN BROWSER

AADAC-001
AADAC-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AADAC-001
ENSP00000232892
ENST00000232892
P22760 [Direct mapping]
Arylacetamide deacetylase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004806 [triglyceride lipase activity]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006805 [xenobiotic metabolic process]
GO:0008152 [metabolic process]
GO:0010898 [positive regulation of triglyceride catabolic process]
GO:0016021 [integral component of membrane]
GO:0016298 [lipase activity]
GO:0016787 [hydrolase activity]
GO:0017171 [serine hydrolase activity]
GO:0019213 [deacetylase activity]
GO:0044281 [small molecule metabolic process]
GO:0052689 [carboxylic ester hydrolase activity]
Show all
399 aa
45.7 kDa
No 0
AADAC-002
ENSP00000419620
ENST00000488869
C9K0E9 [Direct mapping]
Arylacetamide deacetylase
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
GO:0016787 [hydrolase activity]
Show all
204 aa
23.1 kDa
No 0

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