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WNT6

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GENERAL INFORMATION

Gene name

 WNT6

Gene description

 Wingless-type MMTV integration site family, member 6

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enriched (BEWO)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (BEWO)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 WNT6

Synonyms

Description

 Wingless-type MMTV integration site family, member 6 (HGNC Symbol)

Entrez gene summary

 The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is overexpressed in cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell line. The gene overexpression may play key roles in carcinogenesis. This gene and the WNT10A gene are clustered in the chromosome 2q35 region. The protein encoded by this gene is 97% identical to the mouse Wnt6 protein at the amino acid level. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q35

Chromosome location (bp)

 218859821 - 218874233

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115596 (version 83.38)

Entrez gene

 7475

UniProt

 Q9Y6F9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y6F9

Antibodypedia

 WNT6 antibodies

PROTEIN BROWSER
WNT6-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
WNT6-001
ENSP00000233948
ENST00000233948
Q9Y6F9 [Direct mapping]
Protein Wnt-6
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Show all
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0005102 [receptor binding]
GO:0005109 [frizzled binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005796 [Golgi lumen]
GO:0005886 [plasma membrane]
GO:0007275 [multicellular organismal development]
GO:0009798 [axis specification]
GO:0009986 [cell surface]
GO:0010628 [positive regulation of gene expression]
GO:0016055 [Wnt signaling pathway]
GO:0030182 [neuron differentiation]
GO:0030666 [endocytic vesicle membrane]
GO:0042475 [odontogenesis of dentin-containing tooth]
GO:0045165 [cell fate commitment]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0060684 [epithelial-mesenchymal cell signaling]
GO:0061303 [cornea development in camera-type eye]
GO:0070062 [extracellular exosome]
GO:0070172 [positive regulation of tooth mineralization]
GO:0071300 [cellular response to retinoic acid]
GO:0072079 [nephron tubule formation]
GO:0072080 [nephron tubule development]
Show all
 365 aa
39.7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.