Tissue expression of WNT6 - Summary - The Human Protein Atlas

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WNT6

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	WNT6
Gene description	Wingless-type MMTV integration site family, member 6
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (placenta)
GTEx:	Mixed
FANTOM5:	Tissue enhanced (caudate)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA052031
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (placenta)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (caudate)

GENE INFORMATION
Gene name	WNT6
Synonyms
Description	Wingless-type MMTV integration site family, member 6 (HGNC Symbol)
Entrez gene summary	The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is overexpressed in cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell line. The gene overexpression may play key roles in carcinogenesis. This gene and the WNT10A gene are clustered in the chromosome 2q35 region. The protein encoded by this gene is 97% identical to the mouse Wnt6 protein at the amino acid level. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q35
Chromosome location (bp)	218859821 - 218874233
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115596 (version 83.38)
Entrez gene	7475
UniProt	Q9Y6F9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y6F9
Antibodypedia	WNT6 antibodies

PROTEIN BROWSER

WNT6-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
WNT6-001 ENSP00000233948 ENST00000233948	Q9Y6F9 [Direct mapping] Protein Wnt-6 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0001658 [branching involved in ureteric bud morphogenesis] GO:0005102 [receptor binding] GO:0005109 [frizzled binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0005788 [endoplasmic reticulum lumen] GO:0005796 [Golgi lumen] GO:0005886 [plasma membrane] GO:0007275 [multicellular organismal development] GO:0009798 [axis specification] GO:0009986 [cell surface] GO:0010628 [positive regulation of gene expression] GO:0016055 [Wnt signaling pathway] GO:0030182 [neuron differentiation] GO:0030666 [endocytic vesicle membrane] GO:0042475 [odontogenesis of dentin-containing tooth] GO:0045165 [cell fate commitment] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0060684 [epithelial-mesenchymal cell signaling] GO:0061303 [cornea development in camera-type eye] GO:0070062 [extracellular exosome] GO:0070172 [positive regulation of tooth mineralization] GO:0071300 [cellular response to retinoic acid] GO:0072079 [nephron tubule formation] GO:0072080 [nephron tubule development] Show all	365 aa 39.7 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.