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Estimation of protein expression could not be performed. View primary data.
ANTIBODY IHC RELIABILITY
Data reliability description
RNA-based expert annotation gave inconclusive results. Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.
Several cases of renal cancers showed moderate to strong cytoplasmic, membranous and nuclear staining while hepatocellular cancers exhibited moderate cytoplasmic and nuclear positivity. A fraction of cells of urothelial cancer showed strong positivity. Remaining malignant tissues were weakly stained or negative.
GENE INFORMATION
Gene name
WNT6
Synonyms
Description
Wingless-type MMTV integration site family, member 6 (HGNC Symbol)
Entrez gene summary
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is overexpressed in cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell line. The gene overexpression may play key roles in carcinogenesis. This gene and the WNT10A gene are clustered in the chromosome 2q35 region. The protein encoded by this gene is 97% identical to the mouse Wnt6 protein at the amino acid level. [provided by RefSeq, Jul 2008]