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ASH1L

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GENERAL INFORMATION

Gene name

 ASH1L

Gene description

 Ash1 (absent, small, or homeotic)-like (Drosophila)

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the Golgi apparatus & nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported), Golgi apparatus (approved)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA004806
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ASSAYS
RNA expression
Human cells
Custom data

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the Golgi apparatus & nucleoplasm.

Main location

 Nucleoplasm (supported), Golgi apparatus (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

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Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA004806 A-431 Golgi apparatus
HPA004806 U-2 OS Nucleoplasm
Golgi apparatus

CUSTOM DATA

 

 

 
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Antibody

Cell line

Assay

Description
HPA004806 U-2 OS Image Co-localization with the cis-Golgi marker GM130/GOLGA2 (RRID:AB_398141) for a refined protein localization within the Golgi apparatus in U-2 OS cells. ASH1L localizes to the Golgi apparatus, and is only detected in the cis-Golgi compartment.

GENE INFORMATION

Gene name

 ASH1L (HGNC Symbol)

Synonyms

 ASH1, ASH1L1, huASH1, KMT2H

Description

 Ash1 (absent, small, or homeotic)-like (Drosophila) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the trithorax group of transcriptional activators. The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. It is localized to many small speckles in the nucleus, and also to cell-cell tight junctions. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q22

Chromosome location (bp)

 155335268 - 155562807

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000116539 (version 83.38)

Entrez gene

 55870

UniProt

 Q9NR48 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NR48

Antibodypedia

 ASH1L antibodies

PROTEIN BROWSER
ASH1L-001
ASH1L-002
ASH1L-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ASH1L-001
ENSP00000357330
ENST00000368346
Q9NR48 [Direct mapping]
Histone-lysine N-methyltransferase ASH1L
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005923 [bicellular tight junction]
GO:0006323 [DNA packaging]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007267 [cell-cell signaling]
GO:0008270 [zinc ion binding]
GO:0018024 [histone-lysine N-methyltransferase activity]
GO:0046975 [histone methyltransferase activity (H3-K36 specific)]
GO:0070062 [extracellular exosome]
GO:0097676 [histone H3-K36 dimethylation]
Show all
 2969 aa
332.8 kDa 		No 0
ASH1L-002
ENSP00000376204
ENST00000392403
Q9NR48 [Direct mapping]
Histone-lysine N-methyltransferase ASH1L
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002674 [negative regulation of acute inflammatory response]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005923 [bicellular tight junction]
GO:0006323 [DNA packaging]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007267 [cell-cell signaling]
GO:0008270 [zinc ion binding]
GO:0018024 [histone-lysine N-methyltransferase activity]
GO:0032635 [interleukin-6 production]
GO:0042800 [histone methyltransferase activity (H3-K4 specific)]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043409 [negative regulation of MAPK cascade]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046975 [histone methyltransferase activity (H3-K36 specific)]
GO:0050728 [negative regulation of inflammatory response]
GO:0051568 [histone H3-K4 methylation]
GO:0070062 [extracellular exosome]
GO:0097676 [histone H3-K36 dimethylation]
Show all
 2964 aa
332.2 kDa 		No 0
ASH1L-006
ENSP00000449283
ENST00000548830
F8VWK7 [Direct mapping]
Histone-lysine N-methyltransferase ASH1L
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 177 aa
19.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.