Fields »
ABOUT
HELP
BLOG
ASH1L

GENERAL INFORMATION

Gene name

 ASH1L

Gene description

 Ash1 (absent, small, or homeotic)-like (Drosophila)

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA004806
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Breast
N/A
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ASH1L (HGNC Symbol)

Synonyms

 ASH1, ASH1L1, huASH1, KMT2H

Description

 Ash1 (absent, small, or homeotic)-like (Drosophila) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the trithorax group of transcriptional activators. The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. It is localized to many small speckles in the nucleus, and also to cell-cell tight junctions. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q22

Chromosome location (bp)

 155335268 - 155562807

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000116539 (version 83.38)

Entrez gene

 55870

UniProt

 Q9NR48 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NR48

Antibodypedia

 ASH1L antibodies

PROTEIN BROWSER
ASH1L-001
ASH1L-002
ASH1L-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ASH1L-001
ENSP00000357330
ENST00000368346
Q9NR48 [Direct mapping]
Histone-lysine N-methyltransferase ASH1L
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005923 [bicellular tight junction]
GO:0006323 [DNA packaging]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007267 [cell-cell signaling]
GO:0008270 [zinc ion binding]
GO:0018024 [histone-lysine N-methyltransferase activity]
GO:0046975 [histone methyltransferase activity (H3-K36 specific)]
GO:0070062 [extracellular exosome]
GO:0097676 [histone H3-K36 dimethylation]
Show all
 2969 aa
332.8 kDa 		No 0
ASH1L-002
ENSP00000376204
ENST00000392403
Q9NR48 [Direct mapping]
Histone-lysine N-methyltransferase ASH1L
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002674 [negative regulation of acute inflammatory response]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005923 [bicellular tight junction]
GO:0006323 [DNA packaging]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007267 [cell-cell signaling]
GO:0008270 [zinc ion binding]
GO:0018024 [histone-lysine N-methyltransferase activity]
GO:0032635 [interleukin-6 production]
GO:0042800 [histone methyltransferase activity (H3-K4 specific)]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043409 [negative regulation of MAPK cascade]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046975 [histone methyltransferase activity (H3-K36 specific)]
GO:0050728 [negative regulation of inflammatory response]
GO:0051568 [histone H3-K4 methylation]
GO:0070062 [extracellular exosome]
GO:0097676 [histone H3-K36 dimethylation]
Show all
 2964 aa
332.2 kDa 		No 0
ASH1L-006
ENSP00000449283
ENST00000548830
F8VWK7 [Direct mapping]
Histone-lysine N-methyltransferase ASH1L
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 177 aa
19.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.