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Moderate to strong nuclear staining was observed in a most malignant carcinoids, colorectal, ovarian, prostate and lung cancers as well as several testicular and cervical cancers. Remaining malignancies generally showed weak nuclear and cytoplasmic staining or were negative.
GENE INFORMATION
Gene name
ASH1L (HGNC Symbol)
Synonyms
ASH1, ASH1L1, huASH1, KMT2H
Description
Ash1 (absent, small, or homeotic)-like (Drosophila) (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the trithorax group of transcriptional activators. The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. It is localized to many small speckles in the nucleus, and also to cell-cell tight junctions. [provided by RefSeq, Jul 2008]