Cell atlas - UAP1 - The Human Protein Atlas

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UAP1

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm
	Plasma membrane

Human cell
	Cytosol
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	UAP1
Gene description	UDP-N-acetylglucosamine pyrophosphorylase 1
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol & nucleoplasm. In addition localized to the plasma membrane.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Cytosol (supported)
Additional location	In addition localized to the Plasma membrane (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA014659
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol & nucleoplasm. In addition localized to the plasma membrane.

Main location

Nucleoplasm (approved), Cytosol (supported)

Additional location

Plasma membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA014659	A-431	Nucleoplasm	Spatial
			Plasma membrane	Spatial
			Cytosol	Spatial
	HPA014659	U-2 OS	No staining
	HPA014659	U-251 MG	Nucleoplasm	Spatial
			Plasma membrane	Spatial
			Cytosol	Spatial

GENE INFORMATION
Gene name	UAP1 (HGNC Symbol)
Synonyms	AgX, AGX1, SPAG2
Description	UDP-N-acetylglucosamine pyrophosphorylase 1 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	q23.3
Chromosome location (bp)	162561506 - 162599842
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000117143 (version 83.38)
Entrez gene	6675
UniProt	Q16222 (UniProt - Evidence at protein level)
neXtProt	NX_Q16222
Antibodypedia	UAP1 antibodies

PROTEIN BROWSER

UAP1-001	UAP1-002	UAP1-003	UAP1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UAP1-001 ENSP00000356903 ENST00000367926	Q16222 [Direct mapping] UDP-N-acetylhexosamine pyrophosphorylase UDP-N-acetylgalactosamine pyrophosphorylase UDP-N-acetylglucosamine pyrophosphorylase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003977 [UDP-N-acetylglucosamine diphosphorylase activity] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006047 [UDP-N-acetylglucosamine metabolic process] GO:0006048 [UDP-N-acetylglucosamine biosynthetic process] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0008152 [metabolic process] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030246 [carbohydrate binding] GO:0042802 [identical protein binding] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070569 [uridylyltransferase activity] Show all	505 aa 57 kDa	No	0
UAP1-002 ENSP00000356902 ENST00000367925	Q16222 [Direct mapping] UDP-N-acetylhexosamine pyrophosphorylase UDP-N-acetylgalactosamine pyrophosphorylase UDP-N-acetylglucosamine pyrophosphorylase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003977 [UDP-N-acetylglucosamine diphosphorylase activity] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006048 [UDP-N-acetylglucosamine biosynthetic process] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0008152 [metabolic process] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0042802 [identical protein binding] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070569 [uridylyltransferase activity] Show all	522 aa 58.8 kDa	No	0
UAP1-003 ENSP00000356901 ENST00000367924	Q16222 [Direct mapping] UDP-N-acetylhexosamine pyrophosphorylase UDP-N-acetylgalactosamine pyrophosphorylase UDP-N-acetylglucosamine pyrophosphorylase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003977 [UDP-N-acetylglucosamine diphosphorylase activity] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006048 [UDP-N-acetylglucosamine biosynthetic process] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0008152 [metabolic process] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0042802 [identical protein binding] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070569 [uridylyltransferase activity] Show all	521 aa 58.7 kDa	No	0
UAP1-201 ENSP00000271469 ENST00000271469	Q16222 [Direct mapping] UDP-N-acetylhexosamine pyrophosphorylase UDP-N-acetylgalactosamine pyrophosphorylase UDP-N-acetylglucosamine pyrophosphorylase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003977 [UDP-N-acetylglucosamine diphosphorylase activity] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006048 [UDP-N-acetylglucosamine biosynthetic process] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0008152 [metabolic process] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0042802 [identical protein binding] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070569 [uridylyltransferase activity] Show all	522 aa 58.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.