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UAP1

GENERAL INFORMATION

Gene name

 UAP1

Gene description

 UDP-N-acetylglucosamine pyrophosphorylase 1

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA014659
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA014659

GENE INFORMATION

Gene name

 UAP1 (HGNC Symbol)

Synonyms

 AgX, AGX1, SPAG2

Description

 UDP-N-acetylglucosamine pyrophosphorylase 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 1

Cytoband

 q23.3

Chromosome location (bp)

 162561506 - 162599842

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000117143 (version 83.38)

Entrez gene

 6675

UniProt

 Q16222 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16222

Antibodypedia

 UAP1 antibodies

PROTEIN BROWSER
UAP1-001
UAP1-002
UAP1-003
UAP1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UAP1-001
ENSP00000356903
ENST00000367926
Q16222 [Direct mapping]
UDP-N-acetylhexosamine pyrophosphorylase UDP-N-acetylgalactosamine pyrophosphorylase UDP-N-acetylglucosamine pyrophosphorylase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003977 [UDP-N-acetylglucosamine diphosphorylase activity]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006047 [UDP-N-acetylglucosamine metabolic process]
GO:0006048 [UDP-N-acetylglucosamine biosynthetic process]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0008152 [metabolic process]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030246 [carbohydrate binding]
GO:0042802 [identical protein binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0070569 [uridylyltransferase activity]
Show all
 505 aa
57 kDa 		No 0
UAP1-002
ENSP00000356902
ENST00000367925
Q16222 [Direct mapping]
UDP-N-acetylhexosamine pyrophosphorylase UDP-N-acetylgalactosamine pyrophosphorylase UDP-N-acetylglucosamine pyrophosphorylase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003977 [UDP-N-acetylglucosamine diphosphorylase activity]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006048 [UDP-N-acetylglucosamine biosynthetic process]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0008152 [metabolic process]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0042802 [identical protein binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0070569 [uridylyltransferase activity]
Show all
 522 aa
58.8 kDa 		No 0
UAP1-003
ENSP00000356901
ENST00000367924
Q16222 [Direct mapping]
UDP-N-acetylhexosamine pyrophosphorylase UDP-N-acetylgalactosamine pyrophosphorylase UDP-N-acetylglucosamine pyrophosphorylase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003977 [UDP-N-acetylglucosamine diphosphorylase activity]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006048 [UDP-N-acetylglucosamine biosynthetic process]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0008152 [metabolic process]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0042802 [identical protein binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0070569 [uridylyltransferase activity]
Show all
 521 aa
58.7 kDa 		No 0
UAP1-201
ENSP00000271469
ENST00000271469
Q16222 [Direct mapping]
UDP-N-acetylhexosamine pyrophosphorylase UDP-N-acetylgalactosamine pyrophosphorylase UDP-N-acetylglucosamine pyrophosphorylase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003977 [UDP-N-acetylglucosamine diphosphorylase activity]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006048 [UDP-N-acetylglucosamine biosynthetic process]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0008152 [metabolic process]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0042802 [identical protein binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0070569 [uridylyltransferase activity]
Show all
 522 aa
58.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.