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RPA2

GENERAL INFORMATION

Gene name

 RPA2

Gene description

 Replication protein A2, 32kDa

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA026306 , HPA026309 , CAB016538
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable) and head and neck cancer (favourable).
Cervical cancer p<0.001
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA026306
HPA026309
CAB016538

GENE INFORMATION

Gene name

 RPA2

Synonyms

Description

 Replication protein A2, 32kDa (HGNC Symbol)

Entrez gene summary

Chromosome

 1

Cytoband

 p35.3

Chromosome location (bp)

 27891524 - 27914746

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000117748 (version 83.38)

Entrez gene

 6118

UniProt

 P15927 (UniProt - Evidence at protein level)

neXtProt

 NX_P15927

Antibodypedia

 RPA2 antibodies

PROTEIN BROWSER
RPA2-001
RPA2-002
RPA2-003
RPA2-004
RPA2-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RPA2-001
ENSP00000363021
ENST00000373912
P15927 [Direct mapping]
Replication protein A 32 kDa subunit
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000722 [telomere maintenance via recombination]
GO:0000723 [telomere maintenance]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000781 [chromosome, telomeric region]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0000785 [chromatin]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003684 [damaged DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005662 [DNA replication factor A complex]
GO:0006260 [DNA replication]
GO:0006271 [DNA strand elongation involved in DNA replication]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006284 [base-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006297 [nucleotide-excision repair, DNA gap filling]
GO:0006298 [mismatch repair]
GO:0006302 [double-strand break repair]
GO:0006310 [DNA recombination]
GO:0010569 [regulation of double-strand break repair via homologous recombination]
GO:0016605 [PML body]
GO:0019899 [enzyme binding]
GO:0019903 [protein phosphatase binding]
GO:0019985 [translesion synthesis]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032201 [telomere maintenance via semi-conservative replication]
GO:0033683 [nucleotide-excision repair, DNA incision]
GO:0034605 [cellular response to heat]
GO:0035861 [site of double-strand break]
GO:0036297 [interstrand cross-link repair]
GO:0042276 [error-prone translesion synthesis]
GO:0042769 [DNA damage response, detection of DNA damage]
GO:0070911 [global genome nucleotide-excision repair]
GO:0070987 [error-free translesion synthesis]
GO:1900034 [regulation of cellular response to heat]
GO:2000001 [regulation of DNA damage checkpoint]
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 270 aa
29.2 kDa 		No 0
RPA2-002
ENSP00000363017
ENST00000373909
P15927 [Direct mapping]
Replication protein A 32 kDa subunit
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000722 [telomere maintenance via recombination]
GO:0000723 [telomere maintenance]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000781 [chromosome, telomeric region]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0000785 [chromatin]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003684 [damaged DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005662 [DNA replication factor A complex]
GO:0006260 [DNA replication]
GO:0006271 [DNA strand elongation involved in DNA replication]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006284 [base-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006297 [nucleotide-excision repair, DNA gap filling]
GO:0006298 [mismatch repair]
GO:0006302 [double-strand break repair]
GO:0006310 [DNA recombination]
GO:0010569 [regulation of double-strand break repair via homologous recombination]
GO:0016605 [PML body]
GO:0019899 [enzyme binding]
GO:0019903 [protein phosphatase binding]
GO:0019985 [translesion synthesis]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032201 [telomere maintenance via semi-conservative replication]
GO:0033683 [nucleotide-excision repair, DNA incision]
GO:0034605 [cellular response to heat]
GO:0035861 [site of double-strand break]
GO:0036297 [interstrand cross-link repair]
GO:0042276 [error-prone translesion synthesis]
GO:0042769 [DNA damage response, detection of DNA damage]
GO:0047485 [protein N-terminus binding]
GO:0070911 [global genome nucleotide-excision repair]
GO:0070987 [error-free translesion synthesis]
GO:1900034 [regulation of cellular response to heat]
GO:2000001 [regulation of DNA damage checkpoint]
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 278 aa
30.2 kDa 		No 0
RPA2-003
ENSP00000387649
ENST00000444045
Q5TEJ7 [Direct mapping]
Replication protein A 32 kDa subunit
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003676 [nucleic acid binding]
GO:0005654 [nucleoplasm]
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 179 aa
19.4 kDa 		No 0
RPA2-004
ENSP00000363015
ENST00000313433
P15927 [Direct mapping]
Replication protein A 32 kDa subunit
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000722 [telomere maintenance via recombination]
GO:0000723 [telomere maintenance]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000781 [chromosome, telomeric region]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0000785 [chromatin]
GO:0003676 [nucleic acid binding]
GO:0003684 [damaged DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005662 [DNA replication factor A complex]
GO:0006260 [DNA replication]
GO:0006271 [DNA strand elongation involved in DNA replication]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006284 [base-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006297 [nucleotide-excision repair, DNA gap filling]
GO:0006298 [mismatch repair]
GO:0006302 [double-strand break repair]
GO:0010569 [regulation of double-strand break repair via homologous recombination]
GO:0016605 [PML body]
GO:0019899 [enzyme binding]
GO:0019903 [protein phosphatase binding]
GO:0019985 [translesion synthesis]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032201 [telomere maintenance via semi-conservative replication]
GO:0033683 [nucleotide-excision repair, DNA incision]
GO:0034605 [cellular response to heat]
GO:0035861 [site of double-strand break]
GO:0036297 [interstrand cross-link repair]
GO:0042276 [error-prone translesion synthesis]
GO:0042769 [DNA damage response, detection of DNA damage]
GO:0070911 [global genome nucleotide-excision repair]
GO:0070987 [error-free translesion synthesis]
GO:1900034 [regulation of cellular response to heat]
GO:2000001 [regulation of DNA damage checkpoint]
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 358 aa
38.8 kDa 		No 0
RPA2-005
ENSP00000413541
ENST00000419958
Q5TEJ0 [Direct mapping]
Replication protein A 32 kDa subunit
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005654 [nucleoplasm]
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 122 aa
13.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.