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SPP1

GENERAL INFORMATION

Gene name

 SPP1

Gene description

 Secreted phosphoprotein 1

Protein class

 Cancer-related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (gallbladder, kidney, placenta)
GTEx:Tissue enriched (kidney)
FANTOM5:Tissue enriched (kidney)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in a subset of tissues, most abundant in renal tubules and gallbladder.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Approved based on 2 antibodies.
HPA027541 , CAB002212
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Gallbladder

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (gallbladder, kidney, placenta)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (kidney)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (kidney)

GENE INFORMATION

Gene name

 SPP1 (HGNC Symbol)

Synonyms

 BNSP, BSPI, ETA-1, OPN

Description

 Secreted phosphoprotein 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Chromosome

 4

Cytoband

 q22.1

Chromosome location (bp)

 87975650 - 87983426

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000118785 (version 83.38)

Entrez gene

 6696

UniProt

 P10451 (UniProt - Evidence at protein level)

neXtProt

 NX_P10451

Antibodypedia

 SPP1 antibodies

PROTEIN BROWSER
SPP1-001
SPP1-002
SPP1-003
SPP1-010
SPP1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SPP1-001
ENSP00000378517
ENST00000395080
P10451 [Direct mapping]
Osteopontin
A0A024RDE2 [Target identity:100%; Query identity:100%]
Secreted phosphoprotein 1 (Osteopontin, bone sialoprotein I, early T-lymphocyte activation 1), isoform CRA_b
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001503 [ossification]
GO:0001649 [osteoblast differentiation]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0006954 [inflammatory response]
GO:0007155 [cell adhesion]
GO:0007566 [embryo implantation]
GO:0010033 [response to organic substance]
GO:0010811 [positive regulation of cell-substrate adhesion]
GO:0022617 [extracellular matrix disassembly]
GO:0030154 [cell differentiation]
GO:0030198 [extracellular matrix organization]
GO:0030593 [neutrophil chemotaxis]
GO:0031214 [biomineral tissue development]
GO:0031988 [membrane-bounded vesicle]
GO:0033280 [response to vitamin D]
GO:0042995 [cell projection]
GO:0045177 [apical part of cell]
GO:0045780 [positive regulation of bone resorption]
GO:0046697 [decidualization]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048545 [response to steroid hormone]
GO:0048685 [negative regulation of collateral sprouting of intact axon in response to injury]
GO:0050840 [extracellular matrix binding]
GO:0070062 [extracellular exosome]
GO:0071498 [cellular response to fluid shear stress]
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 314 aa
35.4 kDa 		Yes 0
SPP1-002
ENSP00000237623
ENST00000237623
P10451 [Direct mapping]
Osteopontin
A0A024RDE6 [Target identity:100%; Query identity:100%]
Secreted phosphoprotein 1 (Osteopontin, bone sialoprotein I, early T-lymphocyte activation 1), isoform CRA_c
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001503 [ossification]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0007155 [cell adhesion]
GO:0007566 [embryo implantation]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0031214 [biomineral tissue development]
GO:0033280 [response to vitamin D]
GO:0046697 [decidualization]
GO:0070062 [extracellular exosome]
Show all
 300 aa
33.8 kDa 		Yes 0
SPP1-003
ENSP00000354042
ENST00000360804
P10451 [Direct mapping]
Osteopontin
A0A024RDJ0 [Target identity:100%; Query identity:100%]
Secreted phosphoprotein 1 (Osteopontin, bone sialoprotein I, early T-lymphocyte activation 1), isoform CRA_a
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001503 [ossification]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0007155 [cell adhesion]
GO:0007566 [embryo implantation]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0031214 [biomineral tissue development]
GO:0033280 [response to vitamin D]
GO:0046697 [decidualization]
GO:0070062 [extracellular exosome]
Show all
 287 aa
32.4 kDa 		Yes 0
SPP1-010
ENSP00000422973
ENST00000508233
D6R9C5 [Direct mapping]
Osteopontin
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001503 [ossification]
GO:0007155 [cell adhesion]
Show all
 241 aa
27.1 kDa 		Yes 0
SPP1-201
ENSP00000477824
ENST00000614857
P10451 [Direct mapping]
Osteopontin
F2YQ21 [Target identity:100%; Query identity:100%]
Osteopontin-D
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001503 [ossification]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0007155 [cell adhesion]
GO:0007566 [embryo implantation]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0031214 [biomineral tissue development]
GO:0033280 [response to vitamin D]
GO:0046697 [decidualization]
GO:0070062 [extracellular exosome]
Show all
 292 aa
33 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.