Cell atlas - PPL - The Human Protein Atlas

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PPL

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm
	Plasma membrane

Human cell
	Cytosol
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	PPL
Gene description	Periplakin
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane. In addition localized to the cytosol & nucleoplasm.
RNA cell category	Cell line enhanced (HaCaT, SiHa)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (supported)
Additional location	In addition localized to the Nucleoplasm (approved), Cytosol (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA042550
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HaCaT, SiHa) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane. In addition localized to the cytosol & nucleoplasm.

Main location

Plasma membrane (supported)

Additional location

Nucleoplasm (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA042550	A-431	Nucleoplasm
			Plasma membrane
			Cytosol
	HPA042550	SiHa	Nucleoplasm	Spatial
	HPA042550	SiHa	Plasma membrane	Spatial
	HPA042550	U-2 OS	Nucleoplasm
	HPA042550	U-2 OS	Plasma membrane

GENE INFORMATION
Gene name	PPL
Synonyms
Description	Periplakin (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	p13.3
Chromosome location (bp)	4882507 - 4960741
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000118898 (version 83.38)
Entrez gene	5493
UniProt	O60437 (UniProt - Evidence at protein level)
neXtProt	NX_O60437
Antibodypedia	PPL antibodies

PROTEIN BROWSER

PPL-001	PPL-002	PPL-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PPL-001 ENSP00000340510 ENST00000345988	O60437 [Direct mapping] Periplakin Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0030057 [desmosome] GO:0031424 [keratinization] GO:0070062 [extracellular exosome] Show all	1756 aa 204.7 kDa	No	0
PPL-002 ENSP00000467699 ENST00000592772	K7EQ71 [Direct mapping] Periplakin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005856 [cytoskeleton] Show all	1115 aa 131.4 kDa	No	0
PPL-003 ENSP00000465640 ENST00000590782	K7EKI8 [Direct mapping] Periplakin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005856 [cytoskeleton] Show all	1754 aa 204.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.