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PPL

GENERAL INFORMATION

Gene name

 PPL

Gene description

 Periplakin

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (esophagus, skin)
GTEx:Tissue enhanced (esophagus, vagina)
FANTOM5:Group enriched (cervix, uterine, esophagus, tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Membranous expression in squamous epithelium.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA042550 , HPA059859
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Esophagus

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (esophagus, skin)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus, vagina)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cervix, uterine, esophagus, tonsil)

GENE INFORMATION

Gene name

 PPL

Synonyms

Description

 Periplakin (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 p13.3

Chromosome location (bp)

 4882507 - 4960741

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000118898 (version 83.38)

Entrez gene

 5493

UniProt

 O60437 (UniProt - Evidence at protein level)

neXtProt

 NX_O60437

Antibodypedia

 PPL antibodies

PROTEIN BROWSER
PPL-001
PPL-002
PPL-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PPL-001
ENSP00000340510
ENST00000345988
O60437 [Direct mapping]
Periplakin
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0030057 [desmosome]
GO:0031424 [keratinization]
GO:0070062 [extracellular exosome]
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 1756 aa
204.7 kDa 		No 0
PPL-002
ENSP00000467699
ENST00000592772
K7EQ71 [Direct mapping]
Periplakin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005856 [cytoskeleton]
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 1115 aa
131.4 kDa 		No 0
PPL-003
ENSP00000465640
ENST00000590782
K7EKI8 [Direct mapping]
Periplakin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005856 [cytoskeleton]
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 1754 aa
204.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.