Cell atlas - UCHL3 - The Human Protein Atlas

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UCHL3

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleus

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	UCHL3
Gene description	Ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus & cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved), Cytosol (supported)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA019678
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus & cytosol.

Main location

Nucleus (approved), Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA019678	A-431	Nucleoplasm
	HPA019678	A-431	Cytosol
	HPA019678	U-2 OS	Nucleus	Intensity
	HPA019678	U-2 OS	Cytosol
	HPA019678	U-251 MG	Nucleoplasm
	HPA019678	U-251 MG	Cytosol

GENE INFORMATION
Gene name	UCHL3
Synonyms
Description	Ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the deubiquitinating enzyme family. Members of this family are proteases that catalyze the removal of ubiquitin from polypeptides and are divided into five classes, depending on the mechanism of catalysis. This protein may hydrolyze the ubiquitinyl-N-epsilon amide bond of ubiquitinated proteins to regenerate ubiquitin for another catalytic cycle. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]
Chromosome	13
Cytoband	q22.2
Chromosome location (bp)	75549480 - 75606020
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000118939 (version 83.38)
Entrez gene	7347
UniProt	P15374 (UniProt - Evidence at protein level)
neXtProt	NX_P15374
Antibodypedia	UCHL3 antibodies

PROTEIN BROWSER

UCHL3-001	UCHL3-003	UCHL3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UCHL3-001 ENSP00000366819 ENST00000377595	P15374 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase isozyme L3 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004843 [ubiquitin-specific protease activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0008233 [peptidase activity] GO:0016579 [protein deubiquitination] GO:0030163 [protein catabolic process] GO:0043130 [ubiquitin binding] GO:0070062 [extracellular exosome] Show all	230 aa 26.2 kDa	No	0
UCHL3-003 ENSP00000398189 ENST00000419068	Q5TBK7 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase isozyme L3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004843 [ubiquitin-specific protease activity] GO:0005622 [intracellular] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0016579 [protein deubiquitination] Show all	228 aa 25.5 kDa	No	0
UCHL3-201 ENSP00000477746 ENST00000618773	A0A087WTB8 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004843 [ubiquitin-specific protease activity] GO:0005622 [intracellular] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0016579 [protein deubiquitination] Show all	194 aa 21.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.